T
Tammy Calhoun-Davis
Researcher at University of Texas MD Anderson Cancer Center
Publications - 20
Citations - 3741
Tammy Calhoun-Davis is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Prostate cancer & Cancer stem cell. The author has an hindex of 17, co-authored 20 publications receiving 3384 citations.
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Journal ArticleDOI
The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44
Can Liu,Kevin Kelnar,Bigang Liu,Xin Chen,Tammy Calhoun-Davis,Hangwen Li,Lubna Patrawala,Hong Yan,Collene R. Jeter,Sofia Honorio,Jason F. Wiggins,Andreas G. Bader,Randy Fagin,David F.M. Brown,Dean G. Tang +14 more
TL;DR: This study shows that miR-34a is a key negative regulator of CD44(+) prostate cancer cells and establishes a strong rationale for developing miR -34a as a novel therapeutic agent against prostate CSCs.
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NANOG promotes cancer stem cell characteristics and prostate cancer resistance to androgen deprivation
Collene R. Jeter,Bigang Liu,Xin Liu,Xin Liu,Xin-Xin Chen,Can Liu,Tammy Calhoun-Davis,John Repass,Holm Zaehres,Jianjun Shen,Dean G. Tang +10 more
TL;DR: Gain-of-function studies establish the integral role for NANOG in neoplastic processes and shed light on its mechanisms of action in tumorigenesis, as well as establishing the importance of CXCR4, IGFBP5, CD133 and ALDH1 in this work.
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Hierarchical Organization of Prostate Cancer Cells in Xenograft Tumors: The CD44+α2β1+ Cell Population Is Enriched in Tumor-Initiating Cells
TL;DR: Observations suggest that prostate cancer cells are organized as a hierarchy in tumorigenic potential in the order of CD44 + A2B1 +/hi � CD 44 + A 2B1 � /lo > CD44 � A2b1 +-/hi J CD44� A2 B1 �/lo .
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Functional evidence that the self-renewal gene NANOG regulates human tumor development.
Collene R. Jeter,Mark Badeaux,Grace Choy,Dhyan Chandra,Lubna Patrawala,Can Liu,Tammy Calhoun-Davis,Holm Zaehres,George Q. Daley,Dean G. Tang +9 more
TL;DR: Results demonstrate that NANOG, a cell‐fate regulatory molecule known to be important for ESC self‐renewal, also plays a novel role in tumor development.
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The PSA(-/lo) prostate cancer cell population harbors self-renewing long-term tumor-propagating cells that resist castration.
Jichao Qin,Xin Liu,Xin Liu,Brian Laffin,Xin Chen,Xin Chen,Grace Choy,Collene R. Jeter,Tammy Calhoun-Davis,Hangwen Li,Hangwen Li,Ganesh S. Palapattu,Shen Pang,Kevin Lin,Jiaoti Huang,Ivan Ivanov,Wei Li,Mahipal Suraneni,Dean G. Tang +18 more
TL;DR: This study suggests that PSA(-/lo) cells may represent a critical source of castration-resistant PCa cells.