H
Hangwen Li
Researcher at University of Texas MD Anderson Cancer Center
Publications - 18
Citations - 3149
Hangwen Li is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Cancer stem cell & Prostate cancer. The author has an hindex of 11, co-authored 13 publications receiving 2937 citations. Previous affiliations of Hangwen Li include Houston Methodist Hospital & University of Texas at Austin.
Papers
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Journal ArticleDOI
The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44
Can Liu,Kevin Kelnar,Bigang Liu,Xin Chen,Tammy Calhoun-Davis,Hangwen Li,Lubna Patrawala,Hong Yan,Collene R. Jeter,Sofia Honorio,Jason F. Wiggins,Andreas G. Bader,Randy Fagin,David F.M. Brown,Dean G. Tang +14 more
TL;DR: This study shows that miR-34a is a key negative regulator of CD44(+) prostate cancer cells and establishes a strong rationale for developing miR -34a as a novel therapeutic agent against prostate CSCs.
Journal ArticleDOI
Highly purified CD44 + prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells
Lubna Patrawala,Tammy Calhoun,Robin Schneider-Broussard,Hangwen Li,Bobby Bhatia,Shao Hua Tang,J. G. Reilly,Dhyan Chandra,Jain Zhou,Kent Claypool,Lezlee G Coghlan,Dean G. Tang +11 more
TL;DR: The results suggest that the CD44+ PCa cell population is enriched in tumorigenic and metastatic progenitor cells.
Journal ArticleDOI
The PSA(-/lo) prostate cancer cell population harbors self-renewing long-term tumor-propagating cells that resist castration.
Jichao Qin,Xin Liu,Xin Liu,Brian Laffin,Xin Chen,Xin Chen,Grace Choy,Collene R. Jeter,Tammy Calhoun-Davis,Hangwen Li,Hangwen Li,Ganesh S. Palapattu,Shen Pang,Kevin Lin,Jiaoti Huang,Ivan Ivanov,Wei Li,Mahipal Suraneni,Dean G. Tang +18 more
TL;DR: This study suggests that PSA(-/lo) cells may represent a critical source of castration-resistant PCa cells.
Journal ArticleDOI
PC3 Human Prostate Carcinoma Cell Holoclones Contain Self-renewing Tumor-Initiating Cells
TL;DR: Direct experimental evidence is provided that tumor cell holoclones contain stem-like cells that can initiate serially transplantable tumors and have important implications in understanding morphologic heterogeneities and tumorigenic hierarchies in human epithelial cancer cells.
Journal ArticleDOI
Prostate cancer stem cells and their potential roles in metastasis.
Hangwen Li,Dean G. Tang +1 more
TL;DR: Current knowledge of stem/progenitor cells and CSCs, especially in the context of normal human prostate and prostate cancer, is summarized and the recently gained knowledge on the involvement of C SCs in metastasis is updated.