Lubos Cipak

TL;DR: Cytotoxicity was measured in‐vitro using a primary biochemical screening according to Oyama and Eagle, and the growth inhibition assay, and apoptosis detected as sub‐G0 cell population in cell cycle measurement was proved in 25–100 μg mL−1 berberine‐treated cells by monitoring the apoptotic DNA fragmentation using agarose gel electrophoresis.

TL;DR: The previous studies of the anticancer activity of berberine against the cancer cell lines HeLa and L1210 were extended to the human tumour U937 cell line and the murine melanoma B16 cell line growing in vitro.

TL;DR: Results clearly demonstrate that berberine induces apoptosis of U937 cells through the mitochondrial/caspase-dependent pathway.

TL;DR: It was shown that preincubation of cells with flavonoids can influence cisplatin-induced apoptosis in different way, and combined treatment with QU and cis-Pt showed synergistic effect, however, GA combined with cis- Pt exhibited antagonism on cytotoxicity in L1210 murine leukemia cells.

TL;DR: The authors showed that Rec8 phosphorylation is required for proper chromosome disjunction during meiosis and further showed that the fission yeast casein kinase 1 (CK1) delta/epsilon isoforms Hhp1 and Hhp2 are required for full levels of Rec8, the meiosis-specific alpha-kleisin subunit of cohesin.