K
Karl Mechtler
Researcher at Research Institute of Molecular Pathology
Publications - 278
Citations - 33083
Karl Mechtler is an academic researcher from Research Institute of Molecular Pathology. The author has contributed to research in topics: Cohesin & Proteome. The author has an hindex of 77, co-authored 258 publications receiving 29937 citations. Previous affiliations of Karl Mechtler include Austrian Academy of Sciences & University of Graz.
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Journal ArticleDOI
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.
TL;DR: It is shown that mammalian methyltransferases that selectively methylate histone H3 on lysine 9 (Suv39h HMTases) generate a binding site for HP1 proteins—a family of heterochromatic adaptor molecules implicated in both gene silencing and supra-nucleosomal chromatin structure.
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Regulation of chromatin structure by site-specific histone H3 methyltransferases
Stephen Rea,Frank Eisenhaber,Dónal O'Carroll,Brian D. Strahl,Zu-Wen Sun,Manfred Schmid,Susanne Opravil,Karl Mechtler,Chris P. Ponting,C D Allis,Thomas Jenuwein +10 more
TL;DR: A functional interdependence of site-specific H3 tail modifications is revealed and a dynamic mechanism for the regulation of higher-order chromatin is suggested.
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Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability.
Antoine H.F.M. Peters,Dónal O'Carroll,Harry Scherthan,Karl Mechtler,Stephan Sauer,Christian Schöfer,Klara Weipoltshammer,Michaela Pagani,Monika Lachner,Alexander Kohlmaier,Susanne Opravil,Michael P. Doyle,Maria Sibilia,Thomas Jenuwein +13 more
TL;DR: In vivo data assign a crucial role for pericentric H3-K9 methylation in protecting genome stability, and define the Suv39h HMTases as important epigenetic regulators for mammalian development.
Journal ArticleDOI
Partitioning and Plasticity of Repressive Histone Methylation States in Mammalian Chromatin
Antoine H.F.M. Peters,Stefan Kubicek,Karl Mechtler,Roderick J. O'Sullivan,Alwin A.H.A. Derijck,Laura Perez-Burgos,Alexander Kohlmaier,Susanne Opravil,Makoto Tachibana,Yoichi Shinkai,Joost H.A. Martens,Thomas Jenuwein +11 more
TL;DR: The data underscore the selective presence of distinct histone lysine methylation states in partitioning chromosomal subdomains but also reveal a surprising plasticity in propagating methylation patterns in eukaryotic chromatin.
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Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase.
Stefan Kubicek,Roderick J. O'Sullivan,E. Michael August,Eugene R. Hickey,Qiang Zhang,Miguel L L. Teodoro,Stephen Rea,Karl Mechtler,Jennifer A. Kowalski,Carol Ann Homon,Terence A. Kelly,Thomas Jenuwein +11 more
TL;DR: In this article, the authors identify a biologically active HMTase inhibitor that allows for the transient modulation of H3K9me2 marks in mammalian chromatin and demonstrate that transient incubation of several cell lines with BIX-01294 lowers bulk H3 K 9me2 levels that are restored upon removal of the inhibitor.