L
Luca Grumolato
Researcher at French Institute of Health and Medical Research
Publications - 53
Citations - 1893
Luca Grumolato is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Wnt signaling pathway & Cancer. The author has an hindex of 22, co-authored 50 publications receiving 1661 citations. Previous affiliations of Luca Grumolato include University of Rouen & Icahn School of Medicine at Mount Sinai.
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Journal ArticleDOI
Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors
Luca Grumolato,Guizhong Liu,Phyllus Mong,Raksha Mudbhary,Romi Biswas,Randy Arroyave,Sapna Vijayakumar,Aris N. Economides,Stuart A. Aaronson +8 more
TL;DR: It is demonstrated here that prototype canonical Wnt3a and noncanonical Wnt5a ligands specifically trigger completely unrelated endogenous coreceptors-LRP5/6 and Ror1/2, respectively-through a common mechanism that involves their Wnt-dependent coupling to the Frizzled (Fzd) coreceptor and recruitment of shared components.
Journal ArticleDOI
Canonical Wnts function as potent regulators of osteogenesis by human mesenchymal stem cells.
Guizhong Liu,Sapna Vijayakumar,Luca Grumolato,Randy Arroyave,HuiFang Qiao,Gal Akiri,Stuart A. Aaronson +6 more
TL;DR: This study investigates the functions of canonical Wnts on differentiation of adult multipotent human mesenchymal stem cells (hMSCs) in vitro and in vivo, arguing for an important role of a canonical WNT gradient in hMSC osteogenesis in vivo.
Journal ArticleDOI
Selenoprotein T is a PACAP-regulated gene involved in intracellular Ca2+ mobilization and neuroendocrine secretion
Luca Grumolato,Hafida Ghzili,Maité Montero-Hadjadje,Stéphane Gasman,Jean Lesage,Yannick Tanguy,Ludovic Galas,Djida Ait-Ali,Jérôme Leprince,Nathalie C. Guérineau,Abdel G. Elkahloun,Alain Fournier,Didier Vieau,Hubert Vaudry,Youssef Anouar +14 more
TL;DR: Results suggested a possible role of SelT in PACAP signaling during PC12 cell differentiation and demonstrated the implication of a selenoprotein in the regulation of Ca2+ homeostasis and neuroendocrine secretion in response to a cAMP‐stimulating trophic factor.
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High-Frequency Canonical Wnt Activation in Multiple Sarcoma Subtypes Drives Proliferation through a TCF/β-Catenin Target Gene, CDC25A
Sapna Vijayakumar,Guizhong Liu,Ioana A. Rus,Shen Yao,Yan Chen,Gal Akiri,Luca Grumolato,Stuart A. Aaronson +7 more
TL;DR: In Wnt autocrine cell lines, alterations including overexpression or gene amplification of Wnt ligands and/or LRP5/6 coreceptors and epigenetic silencing of different cell surface Wnt antagonists are identified and inhibited sarcoma cell proliferation both in vitro and in vivo.
Journal ArticleDOI
β-Catenin-independent activation of TCF1/LEF1 in human hematopoietic tumor cells through interaction with ATF2 transcription factors.
Luca Grumolato,Guizhong Liu,Tomomi Haremaki,Sathish Kumar Mungamuri,Phyllus Mong,Gal Akiri,Pablo Lopez-Bergami,Adriana Arita,Youssef Anouar,Marek Mlodzik,Ze'ev Ronai,Joshua Brody,Daniel C. Weinstein,Stuart A. Aaronson +13 more
TL;DR: Together, these findings indicate that, through interaction with ATF2 factors, TCF1/LEF1 promote the growth of hematopoietic malignancies in the absence of β-catenin stabilization, thus establishing a new mechanism for TCF/ LEF1 transcriptional activity distinct from that associated with canonical Wnt signaling.