E
Edward F. Attiyeh
Researcher at Children's Hospital of Philadelphia
Publications - 56
Citations - 7278
Edward F. Attiyeh is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Neuroblastoma & Single-nucleotide polymorphism. The author has an hindex of 30, co-authored 52 publications receiving 6499 citations. Previous affiliations of Edward F. Attiyeh include University of Pennsylvania.
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Journal ArticleDOI
Identification of ALK as a major familial neuroblastoma predisposition gene
Yael P. Mosse,Marci Laudenslager,Luca Longo,Kristina A. Cole,Andrew C. Wood,Edward F. Attiyeh,Michael J. Laquaglia,Rachel Sennett,Jill E. Lynch,Patrizia Perri,Genevieve Laureys,Frank Speleman,Cecilia Kim,Cuiping Hou,Cuiping Hou,Hakon Hakonarson,Hakon Hakonarson,Ali Torkamani,Nicholas J. Schork,Garrett M. Brodeur,Gian Paolo Tonini,Eric F. Rappaport,Marcella Devoto,Marcella Devoto,John M. Maris +24 more
TL;DR: It is demonstrated that heritable mutations of ALK are the main cause of familial neuroblastoma, and that germline or acquired activation of this cell-surface kinase is a tractable therapeutic target for this lethal paediatric malignancy.
Journal ArticleDOI
The genetic landscape of high-risk neuroblastoma
Trevor J. Pugh,Olena Morozova,Edward F. Attiyeh,Edward F. Attiyeh,Shahab Asgharzadeh,Shahab Asgharzadeh,Jun S. Wei,Daniel Auclair,Scott L. Carter,Kristian Cibulskis,Megan Hanna,Megan Hanna,Adam Kiezun,Jaegil Kim,Michael S. Lawrence,Lee Lichenstein,Aaron McKenna,Chandra Sekhar Pedamallu,Chandra Sekhar Pedamallu,Alex H. Ramos,Alex H. Ramos,Erica Shefler,Andrey Sivachenko,Carrie Sougnez,Chip Stewart,Adrian Ally,Inanc Birol,Readman Chiu,Richard Corbett,Martin Hirst,Shaun D. Jackman,Baljit Kamoh,Alireza Hadj Khodabakshi,Martin Krzywinski,Allan Lo,Richard A. Moore,Karen Mungall,Jenny Q. Qian,Angela Tam,Nina Thiessen,Yongjun Zhao,Kristina A. Cole,Kristina A. Cole,Maura Diamond,Maura Diamond,Sharon J. Diskin,Sharon J. Diskin,Yael P. Mosse,Yael P. Mosse,Andrew Wood,Andrew Wood,Lingyun Ji,Lingyun Ji,Richard Sposto,Richard Sposto,Thomas C. Badgett,Wendy B. London,Yvonne Moyer,Yvonne Moyer,Julie M. Gastier-Foster,Julie M. Gastier-Foster,Malcolm A. Smith,Jaime M. Guidry Auvil,Daniela S. Gerhard,Michael D. Hogarty,Michael D. Hogarty,Steven J.M. Jones,Eric S. Lander,Stacey Gabriel,Gad Getz,Robert C. Seeger,Robert C. Seeger,Javed Khan,Marco A. Marra,Matthew Meyerson,Matthew Meyerson,John M. Maris +76 more
TL;DR: The authors reported a low median exonic mutation frequency of 0.60 per Mb (0.48 nonsilent) and notably few recurrently mutated genes in high-risk neuroblastoma.
Journal ArticleDOI
Chromosome 1p and 11q deletions and outcome in neuroblastoma.
Edward F. Attiyeh,Wendy B. London,Yael P. Mosse,Qun Wang,Cynthia Winter,Deepa Khazi,Patrick McGrady,Robert C. Seeger,A. Thomas Look,Hiroyuki Shimada,Garrett M. Brodeur,Susan L. Cohn,Katherine K. Matthay,John M. Maris +13 more
TL;DR: Unb11q LOH and 1p36 LOH are independently associated with a worse outcome in patients with neuroblastoma, and both 1p 36 Loh and unb11Q LOH were independently associatedWith decreased progression-free survival in the subgroup of patients with features of low-risk and intermediate-risk disease.
Journal ArticleDOI
Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations
Thomas F. Eleveld,Derek A. Oldridge,Virginie Bernard,Jan Koster,Leo Colmet Daage,Sharon J. Diskin,Linda Schild,Nadia Bessoltane Bentahar,Angela Bellini,Mathieu Chicard,Eve Lapouble,Valérie Combaret,Patricia Legoix-Né,Jean Michon,Trevor J. Pugh,Lori S. Hart,JulieAnn Rader,Edward F. Attiyeh,Jun S. Wei,Shile Zhang,Arlene Naranjo,Julie M. Gastier-Foster,Michael D. Hogarty,Shahab Asgharzadeh,Malcolm A. Smith,Jaime M. Guidry Auvil,Thomas B.K. Watkins,Danny A. Zwijnenburg,Marli E. Ebus,Peter van Sluis,Anne Hakkert,Esther M. van Wezel,C. Ellen van der Schoot,Ellen M. Westerhout,Johannes H. Schulte,Godelieve A.M. Tytgat,M. Emmy M. Dolman,Isabelle Janoueix-Lerosey,Daniela S Gerhard,Huib N. Caron,Olivier Delattre,Javed Khan,Rogier Versteeg,Gudrun Schleiermacher,Jan J. Molenaar,John M. Maris +45 more
TL;DR: It is shown that RAS-MAPK pathway mutations may function as a biomarker for new therapeutic approaches to refractory disease and provide a rationale for genetic characterization of relapse neuroblastomas.
Journal ArticleDOI
Copy number variation at 1q21.1 associated with neuroblastoma
Sharon J. Diskin,Cuiping Hou,Joseph T. Glessner,Edward F. Attiyeh,Edward F. Attiyeh,Marci Laudenslager,Kristopher R. Bosse,Kristina A. Cole,Yael P. Mosse,Yael P. Mosse,Andrew Wood,Jill E. Lynch,Katlyn Pecor,Maura Diamond,Cynthia Winter,Kai Wang,Cecilia Kim,Elizabeth A. Geiger,Patrick McGrady,Alexandra I. F. Blakemore,Wendy B. London,Tamim H. Shaikh,Tamim H. Shaikh,Jonathan P. Bradfield,Struan F.A. Grant,Struan F.A. Grant,Hongzhe Li,Marcella Devoto,E. Rappaport,E. Rappaport,Hakon Hakonarson,Hakon Hakonarson,John M. Maris,John M. Maris +33 more
TL;DR: The identification of a common CNV at chromosome 1q21.1 associated with neuroblastoma in the discovery set is described and a previously unknown transcript within the CNV that showed high sequence similarity to several neuro Blastoma breakpoint family genes and represents a new member of this gene family (NBPF23).