C
Cuiping Hou
Researcher at Children's Hospital of Philadelphia
Publications - 66
Citations - 9401
Cuiping Hou is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 34, co-authored 59 publications receiving 8597 citations. Previous affiliations of Cuiping Hou include Center for Applied Genomics & University of Pennsylvania.
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Journal ArticleDOI
Autism genome-wide copy number variation reveals ubiquitin and neuronal genes
Joseph T. Glessner,Kai Wang,Guiqing Cai,Olena Korvatska,Cecilia E. Kim,Shawn Wood,Haitao Zhang,Annette Estes,Camille W. Brune,Jonathan P. Bradfield,Marcin Imielinski,Edward C. Frackelton,Jennifer Reichert,Emily L. Crawford,Jeffrey Munson,Patrick M. A. Sleiman,Rosetta M. Chiavacci,Kiran Annaiah,Kelly A. Thomas,Cuiping Hou,Wendy Glaberson,James H. Flory,Frederick G. Otieno,Maria Garris,Latha Soorya,Lambertus Klei,Joseph Piven,Kacie J. Meyer,Evdokia Anagnostou,Takeshi Sakurai,Rachel M. Game,Danielle S. Rudd,Danielle Zurawiecki,Christopher J. McDougle,Lea K. Davis,Judith Miller,David J. Posey,Shana M. Michaels,Alexander Kolevzon,Jeremy M. Silverman,Raphael Bernier,Susan E. Levy,Robert T. Schultz,Geraldine Dawson,Thomas Owley,William M. McMahon,Thomas H. Wassink,John A. Sweeney,John I. Nurnberger,Hilary Coon,James S. Sutcliffe,Nancy J. Minshew,Struan F.A. Grant,Maja Bucan,Edwin H. Cook,Joseph D. Buxbaum,Bernie Devlin,Gerard D. Schellenberg,Hakon Hakonarson +58 more
TL;DR: Several new susceptibility genes encoding neuronal cell-adhesion molecules, including NLGN1 and ASTN2, were enriched with CNVs in ASD cases compared to controls, and duplications 55 kilobases upstream of complementary DNA AK123120 indicate that these two important gene networks expressed within the central nervous system may contribute to the genetic susceptibility of ASD.
Journal ArticleDOI
Identification of ALK as a major familial neuroblastoma predisposition gene
Yael P. Mosse,Marci Laudenslager,Luca Longo,Kristina A. Cole,Andrew C. Wood,Edward F. Attiyeh,Michael J. Laquaglia,Rachel Sennett,Jill E. Lynch,Patrizia Perri,Genevieve Laureys,Frank Speleman,Cecilia Kim,Cuiping Hou,Cuiping Hou,Hakon Hakonarson,Hakon Hakonarson,Ali Torkamani,Nicholas J. Schork,Garrett M. Brodeur,Gian Paolo Tonini,Eric F. Rappaport,Marcella Devoto,Marcella Devoto,John M. Maris +24 more
TL;DR: It is demonstrated that heritable mutations of ALK are the main cause of familial neuroblastoma, and that germline or acquired activation of this cell-surface kinase is a tractable therapeutic target for this lethal paediatric malignancy.
Journal ArticleDOI
Common genetic variants on 5p14.1 associate with autism spectrum disorders
Kai Wang,Haitao Zhang,Deqiong Ma,Maja Bucan,Joseph T. Glessner,Brett S. Abrahams,Daria Salyakina,Marcin Imielinski,Jonathan P. Bradfield,Patrick M. A. Sleiman,Cecilia E. Kim,Cuiping Hou,Edward C. Frackelton,Rosetta M. Chiavacci,Nagahide Takahashi,Takeshi Sakurai,Eric F. Rappaport,Clara Lajonchere,Jeffrey Munson,Annette Estes,Olena Korvatska,Joseph Piven,Lisa I. Sonnenblick,Ana I. Alvarez Retuerto,Edward I. Herman,Hongmei Dong,Ted Hutman,Marian Sigman,Sally J Ozonoff,Ami Klin,Thomas Owley,John A. Sweeney,Camille W. Brune,Rita M. Cantor,Raphael Bernier,John R. Gilbert,Michael L. Cuccaro,William M. McMahon,Judith Miller,Matthew W. State,Thomas H. Wassink,Hilary Coon,Susan E. Levy,Robert T. Schultz,John I. Nurnberger,Jonathan L. Haines,James S. Sutcliffe,Edwin H. Cook,Nancy J. Minshew,Joseph D. Buxbaum,Geraldine Dawson,Struan F.A. Grant,Daniel H. Geschwind,Margaret A. Pericak-Vance,Gerard D. Schellenberg,Hakon Hakonarson +55 more
TL;DR: The results implicate neuronal cell-adhesion molecules in the pathogenesis of ASDs, and represent, to the authors' knowledge, the first demonstration of genome-wide significant association of common variants with susceptibility to ASDs.
Journal ArticleDOI
Common variants at five new loci associated with early-onset inflammatory bowel disease.
Marcin Imielinski,Robert N. Baldassano,Anne M. Griffiths,Richard K Russell,Vito Annese,Marla Dubinsky,Subra Kugathasan,Jonathan P. Bradfield,Thomas D. Walters,Patrick M. A. Sleiman,Cecilia E. Kim,Aleixo M. Muise,Kai Wang,Joseph T. Glessner,Shehzad Ahmed Saeed,Haitao Zhang,Edward C. Frackelton,Cuiping Hou,James H. Flory,George Otieno,Rosetta M. Chiavacci,Robert W. Grundmeier,Massimo Castro,Anna Latiano,Bruno Dallapiccola,Joanne M. Stempak,Debra J. Abrams,Kent D. Taylor,Dermot P.B. McGovern,Melvin B. Heyman,George D. Ferry,Barbara S. Kirschner,Jessica T. Lee,Jonah Essers,Richard J. Grand,Michael C. Stephens,Arie Levine,David A. Piccoli,Johan Van Limbergen,Salvatore Cucchiara,Dimitri S. Monos,Stephen L. Guthery,Lee A. Denson,David C. Wilson,Struan F.A. Grant,Mark J. Daly,Mark S. Silverberg,Jack Satsangi,Hakon Hakonarson +48 more
TL;DR: The results of a genome-wide association study in early-onset IBD involving 3,426 affected individuals and 11,963 genetically matched controls recruited through international collaborations in Europe and North America are reported, thereby extending the results from a previous study of 1,011 individuals with early-onset IBD.
Journal ArticleDOI
Copy number variation at 1q21.1 associated with neuroblastoma
Sharon J. Diskin,Cuiping Hou,Joseph T. Glessner,Edward F. Attiyeh,Edward F. Attiyeh,Marci Laudenslager,Kristopher R. Bosse,Kristina A. Cole,Yael P. Mosse,Yael P. Mosse,Andrew Wood,Jill E. Lynch,Katlyn Pecor,Maura Diamond,Cynthia Winter,Kai Wang,Cecilia Kim,Elizabeth A. Geiger,Patrick McGrady,Alexandra I. F. Blakemore,Wendy B. London,Tamim H. Shaikh,Tamim H. Shaikh,Jonathan P. Bradfield,Struan F.A. Grant,Struan F.A. Grant,Hongzhe Li,Marcella Devoto,E. Rappaport,E. Rappaport,Hakon Hakonarson,Hakon Hakonarson,John M. Maris,John M. Maris +33 more
TL;DR: The identification of a common CNV at chromosome 1q21.1 associated with neuroblastoma in the discovery set is described and a previously unknown transcript within the CNV that showed high sequence similarity to several neuro Blastoma breakpoint family genes and represents a new member of this gene family (NBPF23).