L
Luca Salvatore De Santo
Researcher at University of Foggia
Publications - 99
Citations - 2577
Luca Salvatore De Santo is an academic researcher from University of Foggia. The author has contributed to research in topics: Transplantation & Heart transplantation. The author has an hindex of 23, co-authored 93 publications receiving 2404 citations. Previous affiliations of Luca Salvatore De Santo include Seconda Università degli Studi di Napoli.
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Journal ArticleDOI
Dose-dependent fetal complications of warfarin in pregnant women with mechanical heart valves.
Nicola Vitale,Marisa De Feo,Luca Salvatore De Santo,Alessio Pollice,Nicola Tedesco,Maurizio Cotrufo +5 more
TL;DR: There is a close dependency between warfarin dosage and fetal complications in patients with mechanical heart valves requiring long-term anticoagulant therapy.
Journal ArticleDOI
Risk of warfarin during pregnancy with mechanical valve prostheses.
Maurizio Cotrufo,Marisa De Feo,Luca Salvatore De Santo,Gianpaolo Romano,Alessandro Della Corte,Attilio Renzulli,Ciro Gallo +6 more
TL;DR: Warfarin daily dosage over 5 mg per day was a significant predictor of poor pregnancy outcome and the risk for pregnancy complications in patients treated with sodium warfarin is higher when the mean daily dose exceeds 5 mg.
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Spatiotemporal patterns of smooth muscle cell changes in ascending aortic dilatation with bicuspid and tricuspid aortic valve stenosis: focus on cell-matrix signaling.
Alessandro Della Corte,Cesare Quarto,Ciro Bancone,Clotilde Castaldo,Franca Di Meglio,Daria Nurzynska,Luca Salvatore De Santo,Marisa De Feo,Michelangelo Scardone,Stefania Montagnani,Maurizio Cotrufo +10 more
TL;DR: Stress-dependent bicuspid aortic valve matrix changes may trigger early apoptosis by inducing cytoskeletal rearrangement, and a matrix-derived cytoskeleton-mediated proapoptotic signaling was evidenced by increased B cl-2-modifying factor-Bcl-2 binding.
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Different patterns of extracellular matrix protein expression in the convexity and the concavity of the dilated aorta with bicuspid aortic valve: preliminary results
Maurizio Cotrufo,Alessandro Della Corte,Luca Salvatore De Santo,Cesare Quarto,Marisa De Feo,Giampaolo Romano,Cristiano Amarelli,Michelangelo Scardone,Franca Di Meglio,Germano Guerra,Maria Scarano,Serena Vitale,Clotilde Castaldo,Stefania Montagnani +13 more
TL;DR: An asymmetric pattern of matrix protein expression was found that was consistent with the asymmetry in wall-stress distribution reported previously, and differences exist between patients with stenosis and those with regurgitation in terms of protein expression and content in the aortic wall.
Journal ArticleDOI
Biomechanical implications of the congenital bicuspid aortic valve: A finite element study of aortic root function from in vivo data
Carlo Angelo Conti,Alessandro Della Corte,Emiliano Votta,Luca Del Viscovo,Ciro Bancone,Luca Salvatore De Santo,Alberto Redaelli +6 more
TL;DR: Aortic valve function is altered in clinically normally functioning bicuspid aortic valves, and the stress location suggests that leaflet stress may play a role in tissue remodeling at the raphe region and in early leaflet degeneration.