Biomechanical implications of the congenital bicuspid aortic valve: A finite element study of aortic root function from in vivo data
Carlo Angelo Conti,Alessandro Della Corte,Emiliano Votta,Luca Del Viscovo,Ciro Bancone,Luca Salvatore De Santo,Alberto Redaelli +6 more
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TLDR
Aortic valve function is altered in clinically normally functioning bicuspid aortic valves, and the stress location suggests that leaflet stress may play a role in tissue remodeling at the raphe region and in early leaflet degeneration.About:
This article is published in The Journal of Thoracic and Cardiovascular Surgery.The article was published on 2010-10-01 and is currently open access. It has received 112 citations till now. The article focuses on the topics: Bicuspid aortic valve & Bicuspid valve.read more
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Bicuspid Aortic Valve: Identifying Knowledge Gaps and Rising to the Challenge From the International Bicuspid Aortic Valve Consortium (BAVCon)
Hector I. Michelena,Siddharth K. Prakash,Alessandro Della Corte,Malenka M. Bissell,Nandan S. Anavekar,Patrick Mathieu,Yohan Bossé,Giuseppe Limongelli,Eduardo Bossone,D. Woodrow Benson,Patrizio Lancellotti,Eric M. Isselbacher,Eric M. Isselbacher,Maurice Enriquez-Sarano,Thoralf M. Sundt,Philippe Pibarot,Artur Evangelista,Dianna M. Milewicz,Simon C. Body,Simon C. Body,Simon C. Body +20 more
TL;DR: This review describes the current knowledge of BAV, and proposes a roadmap to discovery based on current imaging, molecular biology, and genetic tools, recognizing their advantages and limitations.
Journal ArticleDOI
Calcific Aortic Valve Disease: A Consensus Summary From the Alliance of Investigators on Calcific Aortic Valve Disease
Katherine E. Yutzey,Linda L. Demer,Simon C. Body,Gordon S. Huggins,Dwight A. Towler,Cecilia M. Giachelli,Marion A. Hofmann-Bowman,Douglas P. Mortlock,Melissa B. Rogers,Mehran M. Sadeghi,Mehran M. Sadeghi,Elena Aikawa +11 more
TL;DR: A review of the current status of CAVD research and treatment strategies with identification of areas in need of additional investigation for optimal management of this patient population is provided in this article, with the goals of identifying individuals at risk, developing new therapeutic approaches, and improving diagnostic methods.
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Is aortopathy in bicuspid aortic valve disease a congenital defect or a result of abnormal hemodynamics? A critical reappraisal of a one-sided argument.
TL;DR: Thorough analysis of the recent literature shows a growing amount of evidence supporting the hemodynamic theory of aortopathy in patients with BAV disease, and acknowledges that hemodynamics plays an important role in the development of this disease process.
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Risk of late aortic events after an isolated aortic valve replacement for bicuspid aortic valve stenosis with concomitant ascending aortic dilation.
Evaldas Girdauskas,Kushtrim Disha,Heinrich H Raisin,Maria-Anna Secknus,Michael A. Borger,Thomas Kuntze +5 more
TL;DR: BAV patients with aortic valve stenosis and concomitant mild-to-moderate ascending aortsic dilation are at a considerably low risk of adverse aorti events at 15 years after an isolated AVR.
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Computational assessment of bicuspid aortic valve wall-shear stress: implications for calcific aortic valve disease
TL;DR: The existence of major differences in wall-shear stress pulsatility and magnitude on TAV and BAV leaflets support the existence of a mechano-etiology of CAVD in the BAV.
References
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A classification system for the bicuspid aortic valve from 304 surgical specimens
TL;DR: This classification system, even if used in the major category (type) alone, might be advantageous to better define bicuspid aortic valve disease, facilitate scientific communication, and improve treatment.
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Clinical and Pathophysiological Implications of a Bicuspid Aortic Valve
Paul W.M. Fedak,Subodh Verma,Tirone E. David,Richard L. Leask,Richard D. Weisel,Jagdish Butany +5 more
TL;DR: A concerned 34-year-old airline pilot with a leaky bicuspid aortic valve recently diagnosed by an echocardiogram is contacted, concerned that his disease is hereditary and that his children may also be at risk of losing their job over his condition.
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The bicuspid aortic valve.
Alan C. Braverman,Hasan Güven,Michael A. Beardslee,Majesh Makan,Andrew M. Kates,Marc R. Moon +5 more
TL;DR: The bicuspid aortic valve affects 1 to 2% of the population and may be complicated by aortIC stenosis or aortsic insufficiency and infective endocarditis, which requires continuous surveillance to treat associated lesions and prevent complications.
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Congenitally bicuspid aortic valves: a surgical pathology study of 542 cases (1991 through 1996) and a literature review of 2,715 additional cases.
TL;DR: Functionally, the most common fate of congenitally bicuspid aortic valves was calcific stenosis with or without regurgitation, and because valve replacement is currently the only treatment of symptomatic AS, this disorder will continue to affect health-care costs.
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Biaxial mechanical properties of the native and glutaraldehyde-treated aortic valve cusp: Part II--A structural constitutive model.
TL;DR: In this article, a constitutive model was proposed to describe the complete measured planar biaxial stress-strain relationship of the native and glutaraldehyde-treated aortic valve cusp using a structurally guided approach.