L
Luca Santarelli
Researcher at Hoffmann-La Roche
Publications - 50
Citations - 10300
Luca Santarelli is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Receptor & Gantenerumab. The author has an hindex of 26, co-authored 48 publications receiving 9584 citations. Previous affiliations of Luca Santarelli include Columbia University.
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Journal ArticleDOI
Sembragiline in Moderate Alzheimer's Disease: Results of a Randomized, Double-Blind, Placebo-Controlled Phase II Trial (MAyflOwer RoAD).
Stephane Nave,Rachelle S. Doody,Mercè Boada,Timo Grimmer,Juha-Matti Savola,Paul Delmar,Meike Pauly-Evers,Tania Nikolcheva,Christian Czech,Edilio Borroni,Benedicte Ricci,Juergen Dukart,Marie Mannino,Tracie Carey,Emma Moran,Inma Gilaberte,Nicoletta Milani Muelhardt,Irene Gerlach,Luca Santarelli,Susanne Ostrowitzki,Paulo Fontoura +20 more
TL;DR: This study showed that sembragiline was well-tolerated in patients with moderate AD, and suggested potential effect on neuropsychiatric symptoms and functioning in more behaviorally impaired study population at baseline.
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The alpha-7 nicotinic receptor partial agonist/5-HT3 antagonist RG3487 enhances cortical and hippocampal dopamine and acetylcholine release
Mei Huang,Mei Huang,Anna R. Felix,Sunoh Kwon,David A. Lowe,Tanya L. Wallace,Luca Santarelli,Herbert Y. Meltzer,Herbert Y. Meltzer +8 more
TL;DR: It is suggested that RG3487 enhances DA efflux by nAChR stimulation, whereas ACh efflux is primarily mediated via 5-HT3 receptor antagonism, and thatRG3487 alone or as augmentation may improve cognitive impairment in schizophrenia.
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Characterization of RO5126946, a novel α7 nicotinic acetylcholine receptor positive allosteric modulator
Sunil Sahdeo,Tanya L. Wallace,Ryoko Hirakawa,Frédéric Knoflach,Daniel Bertrand,Hans Maag,Dinah Misner,Geoffrey Tombaugh,Luca Santarelli,Ken A. Brameld,Marcos E. Milla,Donald Button +11 more
TL;DR: Overall, RO5126946 is a novel α7nAChR PAM with cognitive-enhancing properties that improves associative learning in a scopolamine-induced deficit model of fear conditioning in rats and is orally bioavailable and brain-penetrant.
Journal ArticleDOI
P.2.f.027 The efficacy and safety of basimglurant as adjunctive therapy in major depression; a randomised, double-blind, placebo-controlled study
Jorge A. Quiroz,Paul Tamburri,Dennis Deptula,Ludger Banken,Ulrich Beyer,Paulo Fontoura,Luca Santarelli +6 more
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Neuropeptide localization in varicosities of Aplysia sensory neurons is regulated by target and neuromodulators evoking long-term synaptic plasticity.
TL;DR: The results suggest that the postsynaptic target and the neuromodulators not only regulate overall structure but also regulate the level of SN neuropeptide at synaptic sites.