L
Lucas Villas Bôas Hoelz
Researcher at Oswaldo Cruz Foundation
Publications - 38
Citations - 783
Lucas Villas Bôas Hoelz is an academic researcher from Oswaldo Cruz Foundation. The author has contributed to research in topics: Sofosbuvir & Flaviviridae. The author has an hindex of 11, co-authored 37 publications receiving 550 citations. Previous affiliations of Lucas Villas Bôas Hoelz include Federal University of Rio de Janeiro & Federal Fluminense University.
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Journal ArticleDOI
The clinically approved antiviral drug sofosbuvir inhibits Zika virus replication
Carolina Q. Sacramento,Gabrielle R. de Melo,Caroline S. de Freitas,Natasha Rocha,Lucas Villas Bôas Hoelz,Milene D. Miranda,Milene D. Miranda,Natalia Fintelman-Rodrigues,Andressa Marttorelli,André C. Ferreira,Giselle Barbosa-Lima,Juliana L. Abrantes,Juliana L. Abrantes,Yasmine Rangel Vieira,Mônica M. Bastos,Eduardo de Mello Volotão,Estevão Portela Nunes,Diogo A. Tschoeke,Diogo A. Tschoeke,Luciana Leomil,Luciana Leomil,Erick Correia Loiola,Pablo Trindade,Stevens K. Rehen,Fernando A. Bozza,Patrícia T. Bozza,Nubia Boechat,Fabiano L. Thompson,Fabiano L. Thompson,Ana M. B. de Filippis,Karin Brüning,Thiago Moreno L. Souza +31 more
TL;DR: Sofosbuvir inhibited ZIKV replication in different cellular systems, such as hepatoma (Huh-7) cells, neuroblastoma (SH-Sy5y), neural stem cells (NSC) and brain organoids, and induced an increase in A-to-G mutations in the viral genome, highlighting a potential secondary use of sofosBuvir, an anti-HCV drug, against ZikV.
Journal ArticleDOI
Yellow fever virus is susceptible to sofosbuvir both in vitro and in vivo.
Caroline S. de Freitas,Luiza M. Higa,Carolina Q. Sacramento,André C. Ferreira,Patrícia A. Reis,Rodrigo Delvecchio,Fabio L. Monteiro,Giselle Barbosa-Lima,Harrison James Westgarth,Yasmine Rangel Vieira,Mayara Mattos,Natasha Rocha,Lucas Villas Bôas Hoelz,Rennan Papaleo Paes Leme,Mônica M. Bastos,Gisele O. L. Rodrigues,Carla Elizabeth Machado Lopes,Celso Martins Queiroz-Junior,Cristiano Xavier Lima,Vivian Vasconcelos Costa,Mauro M. Teixeira,Fernando A. Bozza,Patrícia T. Bozza,Nubia Boechat,Amilcar Tanuri,Thiago Moreno L. Souza +25 more
TL;DR: Sofosbuvir protected YFV-infected neonatal Swiss mice and adult type I interferon receptor knockout mice from mortality and weight loss and may represent a novel therapeutic option for the treatment of YF.
Journal ArticleDOI
Beyond Members of the Flaviviridae Family, Sofosbuvir Also Inhibits Chikungunya Virus Replication.
André C. Ferreira,Patrícia A. Reis,Caroline S. de Freitas,Carolina Q. Sacramento,Lucas Villas Bôas Hoelz,Mônica M. Bastos,Mayara Mattos,Natasha Rocha,Isaclaudia Gomes de Azevedo Quintanilha,Carolina da S. G. Pedrosa,Leticia R. Q. Souza,Erick Correia Loiola,Pablo Trindade,Yasmine Rangel Vieira,Giselle Barbosa-Lima,Hugo Caire de Castro Faria Neto,Nubia Boechat,Stevens K. Rehen,Karin Brüning,Fernando A. Bozza,Patrícia T. Bozza,Thiago Moreno L. Souza +21 more
TL;DR: It is found that sofosbuvir was three times more selective in inhibiting CHIKV production in human hepatoma cells than ribavirin, a pan-antiviral drug and could pave the way to it becoming a therapeutic option against CF.
Journal ArticleDOI
In vitro antiviral activity of the anti-HCV drugs daclatasvir and sofosbuvir against SARS-CoV-2, the aetiological agent of COVID-19.
Carolina Q. Sacramento,Natalia Fintelman-Rodrigues,Jairo R. Temerozo,Aline de Paula Dias Da Silva,Suelen da Silva Gomes Dias,Carine dos Santos da Silva,André C. Ferreira,Mayara Mattos,Camila R. R. Pão,Caroline S. de Freitas,Vinicius Cardoso Soares,Lucas Villas Bôas Hoelz,Tácio Vinício Amorim Fernandes,Tácio Vinício Amorim Fernandes,Frederico Silva Castelo Branco,Mônica M. Bastos,Nubia Boechat,Felipe Betoni Saraiva,Marcelo Alves Ferreira,Steffen Jockusch,Xuanting Wang,Chuanjuan Tao,Minchen Chien,Wei Xie,Dinshaw J. Patel,Aitor Garzia,Thomas Tuschl,James J. Russo,Rajith K. R. Rajoli,Carolina da S. G. Pedrosa,Gabriela Vitória,Leticia R. Q. Souza,Livia Goto-Silva,Marília Zaluar P. Guimarães,Stevens K. Rehen,Andrew Owen,Fernando A. Bozza,Dumith Chequer Bou-Habib,Jingyue Ju,Patrícia T. Bozza,Thiago Moreno L. Souza +40 more
TL;DR: In this paper, the effects of daclatasvir and sofosbuvir on SARS-CoV-2 pandemic were investigated using a pharmacokinetic model.
Journal ArticleDOI
Evaluation of 7-arylaminopyrazolo[1,5-a]pyrimidines as anti-Plasmodium falciparum, antimalarial, and Pf-dihydroorotate dehydrogenase inhibitors
Luís Felipe S.P. Azeredo,Julia Penna Coutinho,Valquíria A. P. Jabor,Patricia R. Feliciano,Maria Cristina Nonato,Carlos R. Kaiser,Carla Maria S. Menezes,Amanda S.O. Hammes,Ernesto Raul Caffarena,Lucas Villas Bôas Hoelz,Nicolli B de Souza,Glaécia A. N. Pereira,Isabela P. Ceravolo,Antoniana U. Krettli,Nubia Boechat,Nubia Boechat +15 more
TL;DR: Fifteen 7-arylpyrazolo[1,5-a]pyrimidine derivatives are designed and synthesized using ring bioisosteric replacement and molecular hybridization of functional groups based on the highly active 5-methyl-N-(naphthalen-2-yl)-2-(trifluoromethyl)- [1,2,4]triazolo-7-amine and showed increased drug activity.