L
Lucia A. Possamai
Researcher at Imperial College London
Publications - 35
Citations - 1832
Lucia A. Possamai is an academic researcher from Imperial College London. The author has contributed to research in topics: Monocyte & Medicine. The author has an hindex of 15, co-authored 24 publications receiving 1370 citations. Previous affiliations of Lucia A. Possamai include University of Alberta & West Middlesex University Hospital.
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Journal ArticleDOI
EUS-guided FNA for diagnosis of solid pancreatic neoplasms: a meta-analysis
Michael Jonathan Hewitt,Mark J. W. McPhail,Lucia A. Possamai,Ameet Dhar,Panagiotis Vlavianos,Kevin J. Monahan +5 more
TL;DR: It is demonstrated that EUS-FNA is a highly accurate diagnostic test for solid neoplasms of the pancreas and should be considered when algorithms for investigating solid pancreatic lesions are being planned.
Journal ArticleDOI
Source and characterization of hepatic macrophages in acetaminophen-induced acute liver failure in humans.
Charalambos G. Antoniades,Charalambos G. Antoniades,Alberto Quaglia,Leonie S. Taams,Ragai R. Mitry,Munther Hussain,Robin Daniel Abeles,Lucia A. Possamai,Matt Bruce,Mark J. W. McPhail,Mark J. W. McPhail,Christopher Starling,Bart E. Wagner,Adrian Barnardo,Sabine Pomplun,Georg Auzinger,William Bernal,Nigel Heaton,Diego Vergani,Mark Thursz,Julia Wendon +20 more
TL;DR: In AALF, the h‐mϕ population is expanded in areas of necrosis, both through proliferation of resident cells and CCL2‐dependent recruitment of circulating monocytes, which indicates that they are implicated in resolution of inflammation/tissue repair processes during AALf.
Journal ArticleDOI
The Role of Monocytes and Macrophages in Acute and Acute-on-Chronic Liver Failure.
Evangelos Triantafyllou,Kevin J. Woollard,Mark J. W. McPhail,Charalambos G. Antoniades,Lucia A. Possamai +4 more
TL;DR: The cellular and molecular mechanisms by which monocytes and macrophages contribute to the pathophysiology of ALF and ACLF are highlighted, considering both hepatic inflammation and systemic immunosuppression.
Journal ArticleDOI
MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure
Evangelos Triantafyllou,Evangelos Triantafyllou,Evangelos Triantafyllou,Oltin T Pop,Lucia A. Possamai,A. Wilhelm,Evaggelia Liaskou,Arjuna Singanayagam,Arjuna Singanayagam,Christine Bernsmeier,Wafa Khamri,G. Petts,Rebecca Dargue,Scott P Davies,Joseph Tickle,Muhammed Yuksel,Vishal C. Patel,Robin Daniel Abeles,Zania Stamataki,Stuart M. Curbishley,Yun Ma,Ian D. Wilson,Muireann Coen,Kevin J. Woollard,Alberto Quaglia,Julia Wendon,Mark Thursz,David H. Adams,Christopher J. Weston,Charalambos G. Antoniades,Charalambos G. Antoniades,Charalambos G. Antoniades +31 more
TL;DR: A hepatoprotective, MerTK+, macrophage phenotype that evolves during the resolution phase following ALF is identified and represents a novel immunotherapeutic target to promote resolution responses following acute liver injury.
Journal ArticleDOI
Modulation of monocyte/macrophage function: A therapeutic strategy in the treatment of acute liver failure
Lucia A. Possamai,Mark Thursz,Julia Wendon,Charalambos G. Antoniades,Charalambos G. Antoniades +4 more
TL;DR: It is argued that although the initial event in ALF is liver cell death, the clinical syndrome of ALF and its complications including multi-organ dysfunction and sepsis, are largely generated by the immune response to liver injury.