O
Oltin T Pop
Researcher at Kantonsspital St. Gallen
Publications - 24
Citations - 753
Oltin T Pop is an academic researcher from Kantonsspital St. Gallen. The author has contributed to research in topics: Medicine & MERTK. The author has an hindex of 9, co-authored 16 publications receiving 455 citations. Previous affiliations of Oltin T Pop include University of Cambridge & Imperial College London.
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Journal ArticleDOI
Patients With Acute-on-Chronic Liver Failure Have Increased Numbers of Regulatory Immune Cells Expressing the Receptor Tyrosine Kinase MERTK
Christine Bernsmeier,Oltin T Pop,Arjuna Singanayagam,Evangelos Triantafyllou,Evangelos Triantafyllou,Vishal C. Patel,Christopher J. Weston,Stuart M. Curbishley,Fouzia Sadiq,Nikhil Vergis,Wafa Khamri,William Bernal,Georg Auzinger,Michael A. Heneghan,Yun Ma,Wayel Jassem,Nigel Heaton,David H. Adams,Alberto Quaglia,Mark Thursz,Julia Wendon,Charalambos G. Antoniades,Charalambos G. Antoniades,Charalambos G. Antoniades +23 more
TL;DR: Patients with ACLF have increased numbers of immunoregulatory monocytes and macrophages that express MERTK and suppress the innate immune response to microbes, and the number of these cells correlates with disease severity and the inflammatory response.
Journal ArticleDOI
MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure
Evangelos Triantafyllou,Evangelos Triantafyllou,Evangelos Triantafyllou,Oltin T Pop,Lucia A. Possamai,A. Wilhelm,Evaggelia Liaskou,Arjuna Singanayagam,Arjuna Singanayagam,Christine Bernsmeier,Wafa Khamri,G. Petts,Rebecca Dargue,Scott P Davies,Joseph Tickle,Muhammed Yuksel,Vishal C. Patel,Robin Daniel Abeles,Zania Stamataki,Stuart M. Curbishley,Yun Ma,Ian D. Wilson,Muireann Coen,Kevin J. Woollard,Alberto Quaglia,Julia Wendon,Mark Thursz,David H. Adams,Christopher J. Weston,Charalambos G. Antoniades,Charalambos G. Antoniades,Charalambos G. Antoniades +31 more
TL;DR: A hepatoprotective, MerTK+, macrophage phenotype that evolves during the resolution phase following ALF is identified and represents a novel immunotherapeutic target to promote resolution responses following acute liver injury.
Journal ArticleDOI
Normothermic Machine Perfusion (NMP) Inhibits Proinflammatory Responses in the Liver and Promotes Regeneration
Wayel Jassem,Wayel Jassem,Emmanuel Xystrakis,Yasmeen G. Ghnewa,Muhammed Yuksel,Oltin T Pop,Marc Martinez-Llordella,Yamen Jabri,X. Huang,Juan José Lozano,Alberto Quaglia,Alberto Sanchez-Fueyo,Constantin C. Coussios,Mohamed Rela,Mohamed Rela,Peter J. Friend,Nigel Heaton,Nigel Heaton,Yun Ma +18 more
TL;DR: Reduced IRI in NMP recipients was the consequence of the combination of inhibiting inflammation and promoting graft regeneration, and the underlying mechanisms were defined.
Journal ArticleDOI
CD14+CD15-HLA-DR- myeloid-derived suppressor cells impair antimicrobial responses in patients with acute-on-chronic liver failure
Christine Bernsmeier,Evangelos Triantafyllou,Robert Brenig,Fanny Lebossé,Arjuna Singanayagam,Vishal C. Patel,Oltin T Pop,Wafa Khamri,Rooshi Nathwani,R. Tidswell,Christopher J. Weston,David H. Adams,Mark Thursz,Julia Wendon,Charalambos G. Antoniades +14 more
TL;DR: Immune paresis in patients with acute-on-chronic liver failure accounts for infection susceptibility and increased mortality, and immunosuppressive mononuclear CD14+HLA-DR− myeloid-derived suppressor cells (M-MDSCs) are expanded in patientswith ACLF.
Journal ArticleDOI
Multivariate metabotyping of plasma predicts survival in patients with decompensated cirrhosis
Mark J. W. McPhail,Mark J. W. McPhail,Debbie L. Shawcross,Matthew R. Lewis,Iona Coltart,Elizabeth J. Want,Charalambos G. Antoniades,Charalambos G. Antoniades,Kiril Veselkov,Evangelos Triantafyllou,Vishal C. Patel,Oltin T Pop,María Gómez-Romero,Michael Kyriakides,Rabiya Zia,Robin Daniel Abeles,Mary M.E. Crossey,Wayel Jassem,John O'Grady,Nigel Heaton,Georg Auzinger,William Bernal,Alberto Quaglia,Muireann Coen,Jeremy K. Nicholson,Julia Wendon,Elaine Holmes,Simon D. Taylor-Robinson +27 more
TL;DR: In this article, the authors investigated whether high-resolution metabolic profiling can determine a metabolic phenotype associated with 90-day survival in decompensated cirrhosis (DC) and found that 1H NMR metabotyping accurately discriminated between surviving and non-surviving patients with DC.