Lucinda L. Miner

TL;DR: Strain distributions are described for open field activity, learning and memory tasks, aggression, sexual and parental behaviors, acoustic startle and prepulse inhibition, and the behavioral actions of ethanol, nicotine, cocaine, opiates, antipsychotics, and anxiolytics.

TL;DR: The results implicate endogenous opioid-peptide actions at mu opiate receptors in several tests of nociceptive responsiveness and support mu receptor mediation of morphine-induced analgesia in tests of spinal and supraspinal analgesia.

TL;DR: Transgenic VMAT2 knockout mice are constructed and novel information about the contributions of synaptic vesicular actions of monoaminergic drugs and neurotoxins are provided and it is suggested that intactaptic vesicle function may contribute more to amphetamine-conditioned reward than to amphetamines-induced locomotion.

TL;DR: A significant relationship was observed between BTX binding in the three brain regions and sensitivity to IV nicotine-induced seizures such that strains with greater concentrations of BTXbinding sites were more sensitive to nicotine- induced seizures than were strains with lower concentrations ofBTX binding sites.

TL;DR: Strain differences for both seizure sensitivity and receptor concentration in the hippocampus may be due to allelic differences at a single autosomal locus, with dominance for low seizure susceptibility and fewer alpha-BTX receptors.