L
Lucy Waskell
Researcher at University of California, San Francisco
Publications - 29
Citations - 1157
Lucy Waskell is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Cytochrome b5 & Cytochrome. The author has an hindex of 17, co-authored 29 publications receiving 1141 citations. Previous affiliations of Lucy Waskell include Veterans Health Administration.
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Journal ArticleDOI
Identification of the binding site on cytochrome P450 2B4 for cytochrome b5 and cytochrome P450 reductase.
TL;DR: These studies indicate that the binding sites for cy tochrome b 5 and cytochrome P450 reductase are, as predicted, located on the proximal surface of cytochromes P450 2B4 and are partially overlapping but not identical.
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Nitrous Oxide Inactivates Methionine Synthetase in Human Liver
TL;DR: Results in humans are similar to those in animals and suggest that inactivation of methionine synthetase may play a role in the development of the pathologic effects seen in patients and medical personnel after exposure to nitrous oxide.
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Fluoride metabolites after prolonged exposure of volunteers and patients to desflurane.
Trevor S. Sutton,Donald D. Koblin,Larry D. Gruenke,Richard B. Weiskopf,Ira J. Rampil,Lucy Waskell,Edmond I. Eger +6 more
TL;DR: Small but significant levels of trifluoroacetic acid were found in both serum and urine from volunteers after exposure to desflurane, indicating that desflhurane strongly resists biodegradation, but a small amount is metabolized in humans.
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The Stoichiometry of the Cytochrome P-450-catalyzed Metabolism of Methoxyflurane and Benzphetamine in the Presence and Absence of Cytochrome b5
TL;DR: The complete stoichiometry of the metabolism of the cytochrome b5 (cyt b5)-requiring substrate, methoxyflurane, by purified cy tochrome P-450 2B4 was compared to that of another substrate, benzphetamine, which does not require cyt b5 for its metabolism.
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Structure and Spectra of Ferrous Dioxygen and Reduced Ferrous Dioxygen Model Cytochrome P450
TL;DR: In this article, the structural effects of the reduction of the dioxygen species are the elongation of the Fe−O and Fe−S bonds, due to the addition of an electron into a molecular orbital of the reduced form.