L
Luigi Adamo
Researcher at Washington University in St. Louis
Publications - 55
Citations - 1860
Luigi Adamo is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 16, co-authored 38 publications receiving 1267 citations. Previous affiliations of Luigi Adamo include Johns Hopkins University & Harvard University.
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Journal ArticleDOI
Biomechanical forces promote embryonic haematopoiesis
Luigi Adamo,Olaia Naveiras,Olaia Naveiras,Pamela L. Wenzel,Pamela L. Wenzel,Shannon McKinney-Freeman,Shannon McKinney-Freeman,Peter J. Mack,Jorge Gracia-Sancho,Astrid Suchy-Dicey,Momoko Yoshimoto,M. William Lensch,M. William Lensch,Mervin C. Yoder,Guillermo García-Cardeña,George Q. Daley,George Q. Daley +16 more
TL;DR: A critical role for biomechanical forces in haematopoietic development is revealed in mouse embryos using mouse embryonic stem cells differentiated in vitro and that abrogation of nitric oxide, a mediator of shear-stress-induced signalling, compromises haem atopOietic potential in vivo and in vivo is revealed.
Journal ArticleDOI
Reappraising the role of inflammation in heart failure.
TL;DR: In the CANTOS trial, targeted anti-cytokine therapy with a monoclonal antibody against IL-1β resulted in improved heart failure outcomes in patients with myocardial infarction with or without established heart failure.
Journal ArticleDOI
Microfluidics-based assessment of cell deformability.
TL;DR: It is shown that stiffer cells have longer transit times than less stiff ones and that cell size significantly influences travel times, and a high-throughput microfluidics-based approach exploits the connection between travel time of a cell through a narrow passage and cell stiffness is presented.
Microfluidics-Based Assessment of Cell Deformability
TL;DR: In this article, a high-throughput microfluidics-based approach that exploits the connection between travel time of a cell through a narrow passage and cell stiffness is presented.
Journal ArticleDOI
Biomechanical forces promote blood development through prostaglandin E2 and the cAMP–PKA signaling axis
Miguel F. Diaz,Nan Li,Hyunjung Lee,Luigi Adamo,Siobahn M. Evans,Hannah E. Willey,Natasha Arora,Natasha Arora,Yu Suke Torisawa,Dwayne A. L. Vickers,Samantha A. Morris,Samantha A. Morris,Olaia Naveiras,Olaia Naveiras,Shashi K. Murthy,Donald E. Ingber,George Q. Daley,George Q. Daley,Guillermo García-Cardeña,Pamela L. Wenzel +19 more
TL;DR: Diaz et al. show that biochemical forces induced by blood flow promote the development of hematopoietic cells at early embryonic stages via induction of prostaglandin E2 and signaling pathways involved in hematoiesis.