L
Luis Acerenza
Researcher at University of the Republic
Publications - 30
Citations - 351
Luis Acerenza is an academic researcher from University of the Republic. The author has contributed to research in topics: Metabolic network & Flux (metabolism). The author has an hindex of 11, co-authored 30 publications receiving 328 citations.
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Product dependence and bifunctionality compromise the ultrasensitivity of signal transduction cascades.
TL;DR: It is demonstrated that the assumptions of the theoretical studies, i.e., irreversibility and absence of product inhibition, were not trivial: when the conversion reactions are close to equilibrium or saturated by their product, “zero-order” ultrasensitivity disappears.
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Cooperativity: a unified view.
Luis Acerenza,Eduardo Mizraji +1 more
TL;DR: The generality of this unified view concluding that it would be fulfilled by every equilibrium model where there is a one-to-one relationship between free and occupied sites is analyzed.
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Constraints, Trade-offs and the Currency of Fitness
TL;DR: At the metabolic level, a linear trade-off between growth and flux variability was found, employing bacterial genome-scale metabolic reconstructions, suggesting that flux variability can be considered as the currency of fitness.
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Source and regulation of flux variability in Escherichia coli.
TL;DR: The growth-flexibility trade-off operates in physiological and evolutionary adaptations, and provides an explanation for the global reorganization occurring in metabolic networks during adaptations to environmental challenges.
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Modular metabolic control analysis of large responses.
Luis Acerenza,Fernando Ortega +1 more
TL;DR: A general MMCA for two modules, not relying on infinitesimal changes and/or proportionality between parameters and rates is developed, and control coefficients and elasticity coefficients for large changes are defined.