H
Hans V. Westerhoff
Researcher at VU University Amsterdam
Publications - 572
Citations - 30436
Hans V. Westerhoff is an academic researcher from VU University Amsterdam. The author has contributed to research in topics: Systems biology & Flux (metabolism). The author has an hindex of 90, co-authored 566 publications receiving 29104 citations. Previous affiliations of Hans V. Westerhoff include National Institutes of Health & Moscow State University.
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Journal ArticleDOI
A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations
Léonie M. Raamsdonk,Bas Teusink,David Broadhurst,Nianshu Zhang,Andrew Hayes,Michael C. Walsh,Jan A. Berden,Kevin M. Brindle,Douglas B. Kell,Jem J. Rowland,Hans V. Westerhoff,Karel van Dam,Stephen G. Oliver +12 more
TL;DR: It is demonstrated how the intracellular concentrations of metabolites can reveal phenotypes for proteins active in metabolic regulation, and this approach to functional analysis, using comparative metabolomics, is called FANCY—an abbreviation for functional analysis by co-responses in yeast.
Journal ArticleDOI
A community-driven global reconstruction of human metabolism
Ines Thiele,Neil Swainston,Ronan M. T. Fleming,Andreas Hoppe,Swagatika Sahoo,Maike K. Aurich,Hulda S. Haraldsdóttir,Monica L. Mo,Ottar Rolfsson,Miranda D. Stobbe,Miranda D. Stobbe,Stefan Gretar Thorleifsson,Rasmus Agren,Christian Bölling,Sergio Bordel,Arvind K. Chavali,Paul D. Dobson,Warwick B. Dunn,Warwick B. Dunn,Lukas Endler,David Hala,Michael Hucka,Duncan Hull,Daniel Jameson,Neema Jamshidi,Jon J. Jonsson,Nick Juty,Sarah M. Keating,Intawat Nookaew,Nicolas Le Novère,Nicolas Le Novère,Naglis Malys,Naglis Malys,Alexander Mazein,Jason A. Papin,Nathan D. Price,Evgeni Selkov,Martin I. Sigurdsson,Evangelos Simeonidis,Evangelos Simeonidis,Nikolaus Sonnenschein,Kieran Smallbone,Anatoly Sorokin,Anatoly Sorokin,Johannes H. G. M. van Beek,Dieter Weichart,Igor Goryanin,Jens Nielsen,Hans V. Westerhoff,Douglas B. Kell,Pedro Mendes,Pedro Mendes,Bernhard O. Palsson,Bernhard O. Palsson +53 more
TL;DR: Recon 2, a community-driven, consensus 'metabolic reconstruction', is described, which is the most comprehensive representation of human metabolism that is applicable to computational modeling and has improved topological and functional features.
Journal ArticleDOI
Can yeast glycolysis be understood in terms of in vitro kinetics of the constituent enzymes? Testing biochemistry.
Bas Teusink,Jutta Passarge,Corinne A. Reijenga,Eugenia Esgalhado,Coen C. van der Weijden,Mike Schepper,Michael C. Walsh,Barbara M. Bakker,Karel van Dam,Hans V. Westerhoff,Hans V. Westerhoff,Jacky L. Snoep +11 more
TL;DR: The in vivo behavior of yeast glycolysis can be understood in terms of the in vitro kinetic properties of the constituent enzymes in nongrowing, anaerobic, compressed Saccharomyces cerevisiae.
Can yeast glycolysis be understood in terms of in vitro kinetics of the constituent enzymes
Bas Teusink,Passarge J,Reijenga Ka,Eugenia Esgalhado,Van Der Weijden Cc,Schepper M,Michael C. Walsh,Barbara M. Bakker,Van Dam K,Hans V. Westerhoff,Jacky L. Snoep +10 more
Journal ArticleDOI
A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology
Markus J. Herrgård,Neil Swainston,Paul D. Dobson,Warwick B. Dunn,K.Yalçın Arga,Mikko Arvas,Nils Blüthgen,Simon Borger,Roeland Costenoble,Matthias Heinemann,Michael Hucka,Nicolas Le Novère,Peter Li,Wolfram Liebermeister,Monica L. Mo,Ana Paula Oliveira,Dina Petranovic,Stephen Pettifer,Evangelos Simeonidis,Kieran Smallbone,Irena Spasic,Dieter Weichart,Roger Brent,David S. Broomhead,Hans V. Westerhoff,Betul Kirdar,Merja Penttilä,Edda Klipp,Bernhard O. Palsson,Uwe Sauer,Stephen G. Oliver,Pedro Mendes,Jens Nielsen,Douglas B. Kell +33 more
TL;DR: This work describes how it has produced a consensus metabolic network reconstruction for S. cerevisiae, and places special emphasis on referencing molecules to persistent databases or using database-independent forms, such as SMILES or InChI strings, as this permits their chemical structure to be represented unambiguously and in a manner that permits automated reasoning.