Showing papers in "Vaccine in 2002"

TL;DR: These findings demonstrate that the eight-plasmid system allows the rapid and reproducible generation of reassortant influenza A viruses for use in the manufacture of vaccines.

TL;DR: Influenza vaccine was effective in reducing influenza-like illness by 35% (95% confidence interval (CI) 19-47%), hospitalization for pneumonia and influenza by 33% (CI 27-38%), mortality following hospitalization by 47% ( CI 25-62); and mortality from all causes by 50% (SI 45-56%).

TL;DR: Aluminum adjuvants have a demonstrated safety profile of over six decades; however, these adjuvant have been associated with severe local reactions such as erythema, subcutaneous nodules and contact hypersensitivity.

TL;DR: It is shown that exposure to varicella is greater in adults living with children and that this exposure is highly protective against zoster, and under the 'best-fit' model, Exposure to varICElla is estimated to boost cell-mediated immunity for an average of 20 years.

TL;DR: This hypothesis provides a different way to view and to probe the enigma of pandemic influenza, and suggests that wild viruses of man acquire a new HA ligand of avian origin more frequently in nature than the authors are presently aware.

TL;DR: Following exposure to interstitial fluid in vitro and in vivo, most antigens are rapidly desorbed from aluminum adjuvants, suggesting that sustained release of antigen from a depot does not significantly contribute to the adjuvant effect of aluminum compounds.

TL;DR: Three of five volunteers who had previously been immunized against rabies virus with a conventional vaccine specifically responded against the peptide antigen after ingesting spinach leaves infected with the recombinant virus, indicating the potential of the plant virus-based expression systems as supplementary oral booster for rabies vaccinations.

TL;DR: Differences on the total serum IgG response induced by particles of different sizes do not result in differences on the IgG1 or IgG2a-type immune responses, suggesting that the antigen processing and presentation is similar in all cases tested for PLGA particles.

TL;DR: It is shown that peptides and proteins engineered to contain a free cys can be chemically coupled to VLPs formed from the hepatitis B core antigen (HBcAg) containing a lys in the immuno-dominant region and steric hindrance of capsid assembly is abrogated.

TL;DR: The choice between the two vaccine types should be based on weighing the advantage of the attractive non-invasive mode of administration of AA-LIV, against serious concerns about the biological risks inherent to large-scale use of infectious influenza virus, in particular the hazard of gene reassortment with non-human influenza virus strains.

TL;DR: The results support the use of the MCM-mimic cocktail in clinical DC immunotherapy trials, but the roles of it's individual constituents remain to be completely defined.

TL;DR: The safety and immunogenicity profile of ChimeriVax-JE vaccine appears to be similar to that of YF 17D, and the new vaccine holds promise for prevention of JE in travelers and residents of endemic countries.

TL;DR: Recombinant replication-defective adenovirus expressing the CS gene from Plasmodium berghei (Ad-PbCS) was found to induce a strong CD8(+) T cell response after intra-dermal or -muscular immunisation, leading to enhanced immunogenicity and substantial protective efficacy.

TL;DR: The biochemical properties of tumor-derived exosomes and, their pre-clinical activity as cancer vaccines are described.

TL;DR: The FML-QuilA vaccine induced a significant, long lasting and strong protective effect against canine kala-azar in the field, and was detected in vaccinees.

TL;DR: The demonstrated feasibility to manufacture a single recombinant vaccine comprising multiple protective open reading frames and the potential use of MPL-SE as a substitute for IL-12, takes us closer to the realization of an affordable and safe Leishmania vaccine.

TL;DR: This work demonstrated that co-administration of plasmids coding for two different antigens did not result in significant interference between the plasmid vectors, and incorporated a DNA prime/protein boost strategy to examine the effect of DNA priming with electroporation on the immune response after a protein boost.

TL;DR: Both IgG antibodies and proliferative responses against TA-CIN were elicited at all three doses and T-cell immunity against the HPV16 E6 and E7 oncoproteins was detected by IFN gamma ELISPOT in 8/11 evaluable subjects vaccinated with the 533 micro g dose.

TL;DR: The therapeutic cocaine vaccine TA-CD was well tolerated with dose related increases in antibody levels, and a high proportion of patients recruited into the study were retained.

TL;DR: When mucosal adjuvanticity of CT was evaluated in aged mice, an early immune dysregulation was evident in the mucosal immune system and potential problems for effective mucosal vaccine development are discussed.

TL;DR: It is concluded that a single inoculation of Ad5-vectored vaccines could be used as a tool to control FMD in outbreak situations.

TL;DR: This review uses copolymer adjuvants as examples to encourage a more sophisticated approach to the study of adjuvant as agents that can influence many parameters of immune responses including the specificity, titer, duration, memory, class, isotype, and avidity of antibody.

TL;DR: Key factors to be taken into account in the construction of Inflexal V are the retention of the natural presentation of antigens, its biodegradability and the presentation of few adverse events.

TL;DR: Having provided decades of reliable, safe service in their relatively simple chemical formulations, adjuvants are likely to be with us, in one form or another, for the indefinite future.

TL;DR: The results suggest that sensitisation of the calves to environmental mycobacteria adversely affected subsequent protective efficacy of BCG, but the results of vaccination with the other two attenuated M. bovis strains indicated that improved tuberculosis vaccines could be developed for such sensitised animals.

TL;DR: A peptide-based vaccine for foot-and-mouth disease (FMD) effective in swine using peptide doses as low as 12.5 microg, and a mild adjuvant that caused no lesions is designed.

TL;DR: In this article, international collaborative working groups, consisting of professional volunteers from developed and developing countries, conduct systematic literature reviews to develop 50-100 adverse events following immunization (AEFI) definitions.

TL;DR: Fusion activity of virosome was not required for MHC class II presentation of antigen, and virosomes are an efficient system for delivery of protein antigens for stimulation of both helper and CTL responses.

TL;DR: The results suggest that the O-antigen of F. tularensis could be considered as a potential component of a subunit vaccine against type B, but not type A strains of F.

TL;DR: The IM route of administering this aluminum hydroxide adsorbed vaccine is safe and has comparable peak anti-PA IgG antibody levels when two doses are administered 4 weeks apart compared to the licensed initial dose schedule of three doses administered 2 weeks apart.