L
Luiz F. L. Reis
Researcher at Ludwig Institute for Cancer Research
Publications - 85
Citations - 7669
Luiz F. L. Reis is an academic researcher from Ludwig Institute for Cancer Research. The author has contributed to research in topics: Tumor necrosis factor alpha & Interferon. The author has an hindex of 36, co-authored 85 publications receiving 7298 citations. Previous affiliations of Luiz F. L. Reis include Universidade Federal de Minas Gerais & University of Freiburg.
Papers
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Journal ArticleDOI
Functional role of type I and type II interferons in antiviral defense.
Ulrike Müller,Ulrich Steinhoff,Luiz F. L. Reis,Silvio Hemmi,Jovan Pavlovic,Rolf M. Zinkernagel,Michel Aguet +6 more
TL;DR: Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.
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Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase.
Yi-Li Yang,Luiz F. L. Reis,Jovan Pavlovic,Adriano Aguzzi,R. Schafer,Aseem Kumar,Bryan R.G. Williams,Michel Aguet,Charles Weissmann +8 more
TL;DR: In embryo fibroblasts from Pkr knockout mice, the induction of type I IFN as well as the activation of NF‐kappa B by pIC, were strongly impaired but restored by priming with IFN, suggesting a pIC‐responsive system independent of PKR is induced by IFN.
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Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF‐1 and NF‐κB
Aseem Kumar,Yi-Li Yang,Vincenzo Flati,Sandy D. Der,Suzanne Kadereit,Amitabha Deb,Jaharul Haque,Luiz F. L. Reis,Charles Weissmann,Bryan R.G. Williams,Bryan R.G. Williams +10 more
TL;DR: In embryo fibroblasts derived from Pkr°/° mice, interferon regulatory factor 1 (IRF‐1) or guanylate binding protein (Gbp) promoter–reporter constructs were unresponsive to IFN‐γ or pIC but response could be restored by co‐transfection with PKR.
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Induction of the transcription factor IRF-1 and interferon-beta mRNAs by cytokines and activators of second-messenger pathways
TL;DR: It appears that IRF-1 may be necessary but not sufficient for IFN-beta induction, and the ability of TNF and IL-1 to increase both IRf-1 and IFn-beta mRNAs may be responsible for some similarities in the actions of T NF, IL- 1, andThe IFNs.
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Critical role of a common transcription factor, IRF-1, in the regulation of IFN-beta and IFN-inducible genes.
TL;DR: The data show that IRF‐1 is essential for the induced expression of the IFN‐beta gene, and indicate an important role of IRf‐1 in the expression ofIFN‐inducible genes and suggest a role for IRF•1 in many other cytokine actions.