Lukas Bestmann

TL;DR: Sevoflurane preconditioning preserves myocardial and renal function as assessed by biochemical markers in patients undergoing coronary artery bypass graft surgery under cardioplegic arrest.

TL;DR: Evidence of a protective role for pharmacological preconditioning by sevoflurane in late cardiac events in CABG patients, which may be related to favourable transcriptional changes in pro- and antiprotective proteins, is provided.

TL;DR: RIPC applied during isoflurane inhalation provides no benefit to the myocardium of patients undergoing on-pump coronary artery bypass grafting and there was no difference in the 6-month cardiovascular outcome.

TL;DR: Perioperative bisoprolol therapy did not affect cardiovascular outcome in these elderly at-risk patients undergoing surgery with spinal block, and carriers of at least one Gly allele of the β1-adrenergic receptor polymorphism Arg389Gly showed a higher number of adverse events.

TL;DR: In this article, the authors found that T cell depletion in Lassa virus-infected HHD mice prevented disease, irrespective of high-level viremia, and the absence of extensive monocyte/macrophage activation in T cell-depleted mice suggested that T-cell responses contribute to deleterious innate inflammatory reactions and LF pathogenesis.