D
Daniel D. Pinschewer
Researcher at University of Basel
Publications - 100
Citations - 5745
Daniel D. Pinschewer is an academic researcher from University of Basel. The author has contributed to research in topics: Lymphocytic choriomeningitis & Virus. The author has an hindex of 38, co-authored 93 publications receiving 5007 citations. Previous affiliations of Daniel D. Pinschewer include World Health Organization & Scripps Research Institute.
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Journal ArticleDOI
Interferons Direct Th2 Cell Reprogramming to Generate a Stable GATA-3+T-bet+ Cell Subset with Combined Th2 and Th1 Cell Functions
Ahmed N. Hegazy,Ahmed N. Hegazy,Michael Peine,Michael Peine,Caroline Helmstetter,Caroline Helmstetter,Isabel Panse,Isabel Panse,Anja Fröhlich,Anja Fröhlich,Andreas Bergthaler,Lukas Flatz,Daniel D. Pinschewer,Andreas Radbruch,Max Löhning,Max Löhning +15 more
TL;DR: Functional reprogramming of unfavorably differentiated Th2 cells may facilitate the establishment of protective immune responses and provide a molecular concept for the long-term coexistence of Th2 and Th1 cell lineage characteristics in single memory T cells.
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FTY720 immunosuppression impairs effector T cell peripheral homing without affecting induction, expansion, and memory.
Daniel D. Pinschewer,Adrian F. Ochsenbein,Bernhard Odermatt,Volker Brinkmann,Hans Hengartner,Rolf M. Zinkernagel +5 more
TL;DR: FTY720 effectively reduced recirculation of CD8+ effector T cells and their recruitment to peripheral lesions without affecting the induction and expansion of immune responses in secondary lymphoid organs, and may offer the potential to treat ongoing organ-specific T cell-mediated immunopathologic disease.
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The Alarmin Interleukin-33 Drives Protective Antiviral CD8+ T Cell Responses
Weldy V. Bonilla,Anja Fröhlich,Anja Fröhlich,Karin A. Senn,Sandra M. Kallert,Marylise Fernandez,Susan R. Johnson,Mario Kreutzfeldt,Mario Kreutzfeldt,Ahmed N. Hegazy,Ahmed N. Hegazy,Christina Schrick,Christina Schrick,Padraic G. Fallon,Roman Klemenz,Susumu Nakae,Heiko Adler,Doron Merkler,Doron Merkler,Doron Merkler,Max Löhning,Max Löhning,Daniel D. Pinschewer +22 more
TL;DR: It is shown that interleukin-33 (IL-33), an alarmin released from necrotic cells, is necessary for potent CD8+ T cell responses to replicating, prototypic RNA and DNA viruses in mice and showed that endogenous material, independently of pathogen-derived molecules, are also required for antiviral immunity.
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Protective long-term antibody memory by antigen-driven and T help-dependent differentiation of long-lived memory B cells to short-lived plasma cells independent of secondary lymphoid organs
Adrian F. Ochsenbein,Daniel D. Pinschewer,Sophie Sierro,Edit Horvath,Hans Hengartner,Rolf M. Zinkernagel +5 more
TL;DR: It is suggested that memory B cells are long-lived in the absence of antigen, nondividing, and relatively resistant to irradiation and must be stimulated by antigen to differentiate to short-lived antibody-secreting plasma cells, a process that is also efficient in the bone marrow and always depends on radiosensitive, specific T help.
Journal ArticleDOI
FTY720: altered lymphocyte traffic results in allograft protection.
TL;DR: The novel immunomodulator FTY720 protects allografts including islets with remarkable potency, apparently without inducing generalized immunosuppression, and increases the intrinsic mobility of lymphocytes, thereby accelerating chemokine-dependent lymphocyte homing to secondary lymphoid tissues.