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Łukasz Kruszyna
Researcher at Poznan University of Medical Sciences
Publications - 28
Citations - 390
Łukasz Kruszyna is an academic researcher from Poznan University of Medical Sciences. The author has contributed to research in topics: Genotype & Population. The author has an hindex of 11, co-authored 26 publications receiving 290 citations.
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Journal ArticleDOI
Clinical pharmacokinetics of clopidogrel and its metabolites in patients with cardiovascular diseases.
Marta Karaźniewicz-Łada,Dorota Danielak,Paweł Burchardt,Łukasz Kruszyna,Anna Komosa,Maciej Lesiak,Franciszek K. Główka +6 more
TL;DR: The Cmax of the active H4 isomer and platelet aggregation measured by the Multiplate analyser may serve as markers of the patient response to clopidogrel therapy.
Journal ArticleDOI
The Proliferation and Differentiation of Adipose-Derived Stem Cells in Neovascularization and Angiogenesis.
Greg Hutchings,Greg Hutchings,Krzysztof Janowicz,Krzysztof Janowicz,Lisa Moncrieff,Lisa Moncrieff,Claudia Dompe,Claudia Dompe,Ewa Strauss,Ewa Strauss,Ievgeniia Kocherova,Mariusz J. Nawrocki,Łukasz Kruszyna,Grzegorz Wąsiatycz,Paweł Antosik,Jamil Awad Shibli,Paul Mozdziak,Bartłomiej Perek,Zbigniew Krasiński,Bartosz Kempisty,Michał Nowicki +20 more
TL;DR: This review aims to investigate the link between ASCs and angiogenesis/neovascularization, with references to current studies, and describes the molecular mechanisms of these processes, as well as ASC differentiation and proliferation.
Journal ArticleDOI
Polymorphic variants of folate metabolism genes and the risk of laryngeal cancer
Łukasz Kruszyna,Margarita Lianeri,Małgorzata Rydzanicz,Marzena Gajecka,Krzysztof Szyfter,Krzysztof Szyfter,Paweł P. Jagodziński +6 more
TL;DR: The significance of the role of the methyl cycle in etiopathogenesis of laryngeal cancer is confirmed and polymorphic variants of genes encoding enzymes of folate and methionine metabolism are examined using PCR-RFLPs.
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Influence of genetic co-factors on the population pharmacokinetic model for clopidogrel and its active thiol metabolite.
Dorota Danielak,Marta Karaźniewicz-Łada,Anna Komosa,Paweł Burchardt,Maciej Lesiak,Łukasz Kruszyna,Agnieszka Graczyk-Szuster,Franciszek K. Główka +7 more
TL;DR: It was found that the only significant covariate was the presence of CYP2C19*2 allele, which had an impact on lower conversion of clopidogrel to H4, and predicted area under the time-concentration curve values was lower in carriers of this allele.
Journal Article
Mutations within protein kinase R-binding domain of NS5A protein of hepatitis C virus (HCV) and specificity of HCV antibodies in pretreatment sera of HCV-chronically infected patients and their effect on the result of treatment.
Dariusz Kmieciak,Łukasz Kruszyna,Paweł Migdalski,Mariusz Łacinski,Jacek Juszczyk,Wiesław H. Trzeciak +5 more
TL;DR: It is indicated that mutations in the PKR-binding domain of HCV genotype 1b do not correlate with outcome of PEG-IFN-alpha/RBV therapy, however, the presence of E2-specific antibodies in the pretreatment sera ofHCV-chronically infected individuals could serve as a prognostic marker predicting the result of treatment, before its initiation.