The Proliferation and Differentiation of Adipose-Derived Stem Cells in Neovascularization and Angiogenesis.
Greg Hutchings,Greg Hutchings,Krzysztof Janowicz,Krzysztof Janowicz,Lisa Moncrieff,Lisa Moncrieff,Claudia Dompe,Claudia Dompe,Ewa Strauss,Ewa Strauss,Ievgeniia Kocherova,Mariusz J. Nawrocki,Łukasz Kruszyna,Grzegorz Wąsiatycz,Paweł Antosik,Jamil Awad Shibli,Paul Mozdziak,Bartłomiej Perek,Zbigniew Krasiński,Bartosz Kempisty,Michał Nowicki +20 more
Reads0
Chats0
TLDR
This review aims to investigate the link between ASCs and angiogenesis/neovascularization, with references to current studies, and describes the molecular mechanisms of these processes, as well as ASC differentiation and proliferation.Abstract:
Neovascularization and angiogenesis are vital processes in the repair of damaged tissue, creating new blood vessel networks and increasing oxygen and nutrient supply for regeneration. The importance of Adipose-derived Mesenchymal Stem Cells (ASCs) contained in the adipose tissue surrounding blood vessel networks to these processes remains unknown and the exact mechanisms responsible for directing adipogenic cell fate remain to be discovered. As adipose tissue contains a heterogenous population of partially differentiated cells of adipocyte lineage; tissue repair, angiogenesis and neovascularization may be closely linked to the function of ASCs in a complex relationship. This review aims to investigate the link between ASCs and angiogenesis/neovascularization, with references to current studies. The molecular mechanisms of these processes, as well as ASC differentiation and proliferation are described in detail. ASCs may differentiate into endothelial cells during neovascularization; however, recent clinical trials have suggested that ASCs may also stimulate angiogenesis and neovascularization indirectly through the release of paracrine factors.read more
Citations
More filters
Journal ArticleDOI
miR-107 inhibits CDK6 expression, differentiation, and lipid storage in human adipocytes
Maria A. Ahonen,P.A. Nidhina Haridas,Raghavendra Mysore,Martin Wabitsch,Pamela Fischer-Posovszky,Vesa M. Olkkonen,Vesa M. Olkkonen +6 more
TL;DR: The data suggests that miR-107 has distinct functional roles in preadipocytes and mature adipocytes, and elevated expression at these different stages of adipocytes may on one hand dampen adipogenesis, and on the other, promote ectopic fatty acid accumulation and reduced glucose tolerance.
Journal ArticleDOI
Mesenchymal stromal cells for bone sarcoma treatment: Roadmap to clinical practice.
Alexandros Stamatopoulos,Theodosios Stamatopoulos,Zakareya Gamie,Eustathios Kenanidis,Ricardo Ribeiro,Kenneth S. Rankin,Craig Gerrand,Kenneth Dalgarno,Eleftherios Tsiridis +8 more
TL;DR: Data from animal models indicates that mesenchymal stromal cells could accelerate pulmonary metastases, promote proliferation of sarcoma cells and increase chemoresistance, and there is preliminary clinical evidence in promoting bone regeneration within large bone defects after surgical excision.
Journal ArticleDOI
gga-miRNA-18b-3p Inhibits Intramuscular Adipocytes Differentiation in Chicken by Targeting the ACOT13 Gene
Guirong Sun,Fang Li,Xiangfei Ma,Junwei Sun,Jiang Ruirui,Yadong Tian,Ruili Han,Guoxi Li,Yanbin Wang,Zhuanjian Li,Xiangtao Kang,Wenting Li +11 more
TL;DR: These findings laid a new theoretical foundation for the study of lipid metabolism, and provided a potential target to improve the meat quality in the poultry industry.
Journal ArticleDOI
Adipose Tissue-Derived Stem Cells: The Biologic Basis and Future Directions for Tissue Engineering
Diana Aparecida Dias Câmara,Jamil Awad Shibli,Eduardo Alexandre Müller,Paulo Luiz de-Sá-Júnior,Allan Saj Porcacchia,Alberto Blay,Nelson F. Lizier +6 more
TL;DR: Self-renewal and potency are presented by MSCs, which implies in an open-source for 3D bioprinting and regenerative medicine, and ASCs can be applied in the designing of tissue engineering products.
Journal ArticleDOI
Three-dimensional bioprinting adipose tissue and mammary Organoids feasible for artificial breast structure regeneration
TL;DR: This review aims to illustrates the available manufacturing methodologies for 3D bioprinting of breast tissue, various biomaterials suitable for breast tissue regeneration, and previous approaches and designs for breast tissues regeneration and highlights the potential of regenerating breast adipose tissue and mammary gland using 3DBiOPrinting.
References
More filters
Journal ArticleDOI
VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
Holger Gerhardt,Matthew Golding,Marcus Fruttiger,Christiana Ruhrberg,Andrea Lundkvist,Alexandra Abramsson,Michael Jeltsch,Christopher A. Mitchell,Kari Alitalo,David T. Shima,Christer Betsholtz +10 more
TL;DR: It is shown here that VEGF-A controls angiogenic sprouting in the early postnatal retina by guiding filopodial extension from specialized endothelial cells situated at the tips of the vascular sprouts.
Journal ArticleDOI
Endothelial Progenitor Cells: Characterization and Role in Vascular Biology
Carmen Urbich,Stefanie Dimmeler +1 more
TL;DR: This review summarizes the mechanisms regulating endothelial progenitor cell–mediated neovascularization and reendothelialization and describes the characterization of the different progenitors cell populations.
Journal ArticleDOI
Adipose-Derived Stem Cells for Regenerative Medicine
TL;DR: The isolation, characterization, and preclinical and clinical application of adipose-derived stem cells (ASCs) are reviewed in this article.
Journal ArticleDOI
Secretion of Angiogenic and Antiapoptotic Factors by Human Adipose Stromal Cells
Jalees Rehman,Dmitry O. Traktuev,Jingling Li,Stephanie Merfeld-Clauss,Constance J. Temm-Grove,Jason E. Bovenkerk,Carrie L. Pell,Brian H. Johnstone,Robert V. Considine,Keith L. March +9 more
TL;DR: The findings suggest that autologous delivery of either native or transduced subcutaneous ASCs, which are regulated by hypoxia, may be a novel therapeutic option to enhance angiogenesis or achieve cardiovascular protection.
Journal ArticleDOI
Plasticity of Human Adipose Lineage Cells Toward Endothelial Cells Physiological and Therapeutic Perspectives
Valérie Planat-Benard,Jean-Sébastien Silvestre,Béatrice Cousin,Mireille André,Maryse Nibbelink,Radia Tamarat,Michel Clergue,Carole Manneville,Corinne Saillan-Barreau,Micheline Duriez,Alain Tedgui,Bernard I. Levy,Luc Pénicaud,Louis Casteilla +13 more
TL;DR: This study demonstrates, for the first time, that adipocytes and endothelial cells have a common progenitor, and highlights the concept that adipose lineage cells represent a suitable new cell source for therapeutic angiogenesis in ischemic disease.