Luke Whitesell

TL;DR: Mechanistic characterization of ML316, a thiohydantoin which kills drug-resistant Candida species at nanomolar concentrations through fungal-selective inhibition of the mitochondrial phosphate carrier Mir1, is reported, establishing ML316 as the first Mir1 inhibitor using genetic, biochemical, and metabolomic approaches.

TL;DR: In this article, the authors investigated the ability of one class of heat-generating nanomaterials called plasmonic nanoantennae to enhance tumor transport in a xenograft model of ovarian cancer.

TL;DR: It is shown that sustained, low-level inhibition of HSP90 both amplifies and diversifies the antigenic repertoire presented by tumor cells on MHC-I molecules through an IFNγ-independent mechanism, which supports reconsideration of the most effective strategy for targeting H SP90 to treat cancers and suggests a practical approach to repurposing current orally bioavailable HSP 90 inhibitors as a new immunotherapeutic strategy.

TL;DR: FKBP12 can endogenously regulate calcineurin activity with therapeutic implications for the treatment of PD by promoting the dephosphorylation of a subset of proteins that contributes to α-syn toxicity.

TL;DR: Synthesis of aza-rocaglates, nitrogen-containing analogues of the rocaglate natural products, is reported, which features ESIPT-mediated (3+2) photocycloaddition of 1-alkyl-2-aryl-3-hydroxyquinolinones with the dipolarophile methyl cinnamate.