L
Lucas B. Sullivan
Researcher at Fred Hutchinson Cancer Research Center
Publications - 47
Citations - 6627
Lucas B. Sullivan is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: Cancer cell & Medicine. The author has an hindex of 18, co-authored 36 publications receiving 4932 citations. Previous affiliations of Lucas B. Sullivan include Massachusetts Institute of Technology & University of Washington.
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Journal ArticleDOI
Reductive carboxylation supports growth in tumour cells with defective mitochondria
Andrew R. Mullen,William W. Wheaton,Eunsook S. Jin,Pei Hsuan Chen,Lucas B. Sullivan,Tzuling Cheng,Youfeng Yang,W. Marston Linehan,Navdeep S. Chandel,Ralph J. DeBerardinis +9 more
TL;DR: These findings reveal the novel induction of a versatile glutamine-dependent pathway that reverses many of the reactions of the canonical CAC, supports tumour cell growth, and explains how cells generate pools of CAC intermediates in the face of impaired mitochondrial metabolism.
Journal ArticleDOI
Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells
Lucas B. Sullivan,Dan Y. Gui,Aaron M. Hosios,Lauren N. Bush,Elizaveta Freinkman,Matthew G. Vander Heiden,Matthew G. Vander Heiden +6 more
TL;DR: It is found that electron acceptors are limiting for producing aspartates, and supplying aspartate enables proliferation of respiration deficient cells in the absence of exogenous electron acceptor.
Journal ArticleDOI
Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis
William W. Wheaton,Samuel E. Weinberg,Robert B. Hamanaka,Saul Soberanes,Lucas B. Sullivan,Elena Anso,Andrea Glasauer,Eric Dufour,Gökhan M. Mutlu,GR Scott Budigner,Navdeep S. Chandel +10 more
TL;DR: In human cancer cells, metformin inhibits mitochondrial complex I (NADH dehydrogenase) activity and cellular respiration, indicating that cancer cells rely exclusively on glycolysis for survival in the presence of meetformin.
Journal ArticleDOI
Mitochondrial reactive oxygen species and cancer
TL;DR: In this article, the authors discuss how cancer-associated mutations and microenvironments can increase production of reactive oxygen species (mROS), which can lead to activation of tumorigenic signaling and metabolic reprogramming.
Journal ArticleDOI
Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer
Shawn M. Davidson,Shawn M. Davidson,Thales Papagiannakopoulos,Benjamin A. Olenchock,Benjamin A. Olenchock,Benjamin A. Olenchock,Julia E. Heyman,Mark A. Keibler,Alba Luengo,Matthew R. Bauer,Abhishek K. Jha,James P. O’Brien,Kerry A. Pierce,Dan Y. Gui,Lucas B. Sullivan,Thomas M. Wasylenko,Lakshmipriya Subbaraj,Christopher R. Chin,Gregory Stephanopolous,Bryan T. Mott,Tyler Jacks,Clary B. Clish,Matthew G. Vander Heiden +22 more
TL;DR: The data suggest that understanding nutrient utilization by tumors can predict metabolic dependencies of cancers in vivo and argue that the in vivo environment is an important determinant of the metabolic phenotype of cancer cells.