Lunhao Bai

TL;DR: In this paper, the P2X7 receptor was found to activate extracellular matrix degradation and pyroptotic inflammation in OA chondrocytes through NF-κB/NLRP3 crosstalk, thus aggravating the symptoms of OA.

TL;DR: It is demonstrated that miR-23a is frequently downregulated in osteosarcoma specimens and cell lines compared with adjacent noncancerous tissues and cell line, and its inhibitory effect on tumor are mediated chiefly through downregulation of SATB1.

TL;DR: It is found that moderate-intensity treadmill exercise could relieve OA and the selective HDAC3 inhibitor RGFP966 could also alleviate inflammation in OA rat model through inhibition of nuclear translocation of NF-kappaB.

TL;DR: PDX suppresses inflammation in chondrocytes in vitro and in vivo, likely through the AMPK/NF-κB signaling pathway, and the results suggest that PDX could be a useful novel therapeutic agent for OA treatment.

TL;DR: The findings indicate that mechanical stress had no therapeutic effects on normal articular cartilage and chondrocytes; mechanical stress only caused damage with excessive stimulation; Still, moderate biomechanical stress could reduce sensitization to the inflammatory response of articular Cartilage and ChondroCytes through the AMPK/NF‐κB signaling pathway.