Lunzhi Yuan

TL;DR: The pharmacological modulation of MST1/2 kinase activities provides a novel approach to potentiate tissue repair and regeneration, with XMU-MP-1 as the first lead for the development of targeted regenerative therapeutics.

TL;DR: The E6F6-like mAbs may provide a novel immunotherapeutic agent against human chronic HBV infection and was possibly associated with its effective in vivo opsonophagocytosis for viral clearance.

TL;DR: This review aims to summarize the animal models currently available for SARS- CoV and MERS-CoV, and their potential use for the study of SARS -CoV-2, and discusses the benefits and caveats of these animal models.

TL;DR: In this article, the authors performed animal studies to infect male and female Syrian hamsters with SARS-CoV-2 and found that the female hamsters showed much lower shedding viral titers, moderate symptoms, and relatively mild lung pathogenesis.

TL;DR: This new humanised mouse model recapitulates the liver cirrhosis induced by human HBV infection, thus providing research opportunities for understanding viral immune pathophysiology and testing antiviral therapies in vivo.