L
Lutz Gieselmann
Researcher at University of Cologne
Publications - 28
Citations - 1290
Lutz Gieselmann is an academic researcher from University of Cologne. The author has contributed to research in topics: Antibody & Neutralization. The author has an hindex of 8, co-authored 19 publications receiving 491 citations.
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Journal ArticleDOI
Post-COVID syndrome in non-hospitalised patients with COVID-19: a longitudinal prospective cohort study.
Max Augustin,Philipp Schommers,Melanie Stecher,Felix Dewald,Lutz Gieselmann,Henning Gruell,Carola Horn,Kanika Vanshylla,Veronica Di Cristanziano,Luise Osebold,Maria Roventa,Toqeer Riaz,Nikolai Tschernoster,Janine Altmueller,Leonard Rose,Susanne Salomon,Vanessa Priesner,Jan Christoffer Luers,Christian Albus,Stephan Rosenkranz,Birgit S. Gathof,Gerd Fätkenheuer,Michael Hallek,Florian Klein,Isabelle Suárez,Clara Lehmann +25 more
TL;DR: The on-going presence of either shortness of breath, anosmia, ageusia or fatigue as long-lasting symptoms even in non-hospitalised patients was observed at four and seven months post-infection and summarised as post-COVID syndrome (PCS).
Journal ArticleDOI
Longitudinal Isolation of Potent Near-Germline SARS-CoV-2-Neutralizing Antibodies from COVID-19 Patients.
Christoph Kreer,Matthias Zehner,Timm Weber,Meryem S. Ercanoglu,Lutz Gieselmann,Cornelius Rohde,Sandro Halwe,M. Korenkov,Philipp Schommers,Kanika Vanshylla,Veronica Di Cristanziano,Hanna Janicki,Reinhild Brinker,Artem Ashurov,Verena Krähling,Alexandra Kupke,Hadas Cohen-Dvashi,Manuel Koch,Jan Mathis Eckert,Simone Lederer,Nico Pfeifer,Timo Wolf,Maria J G T Vehreschild,Clemens M. Wendtner,Ron Diskin,Henning Gruell,Stephan Becker,Florian Klein +27 more
TL;DR: It is demonstrated that SARS-CoV-2-neutralizing antibodies are readily generated from a diverse pool of precursors, fostering hope for rapid induction of a protective immune response upon vaccination.
Journal ArticleDOI
Kinetics and correlates of the neutralizing antibody response to SARS-CoV-2 infection in humans.
Kanika Vanshylla,Veronica Di Cristanziano,Franziska Kleipass,Felix Dewald,Philipp Schommers,Lutz Gieselmann,Henning Gruell,Maike Schlotz,Meryem S. Ercanoglu,Ricarda Stumpf,Petra Mayer,Matthias Zehner,Eva Heger,Wibke Johannis,Carola Horn,Isabelle Suárez,Norma Jung,Susanne Salomon,Kirsten Alexandra Eberhardt,Kirsten Alexandra Eberhardt,Birgit Gathof,Gerd Fätkenheuer,Nico Pfeifer,Ralf Eggeling,Max Augustin,Clara Lehmann,Florian Klein +26 more
TL;DR: In this article, the authors evaluated SARS-CoV-2 antibody dynamics over 10 months in 963 individuals who predominantly experienced mild COVID-19 and found that approximately 3% of individuals demonstrated exceptional SARSCoV2 neutralization, with these "elite neutralizers" also possessing SARS CoV-1 cross-neutralizing IgG.
Journal ArticleDOI
Polyclonal and convergent antibody response to Ebola virus vaccine rVSV-ZEBOV.
Stefanie A Ehrhardt,Matthias Zehner,Verena Krähling,Hadas Cohen-Dvashi,Christoph Kreer,Nadav Elad,Henning Gruell,Meryem S. Ercanoglu,Philipp Schommers,Lutz Gieselmann,Ralf Eggeling,Christine Dahlke,Christine Dahlke,Timo Wolf,Nico Pfeifer,Marylyn M. Addo,Marylyn M. Addo,Ron Diskin,Stephan Becker,Florian Klein +19 more
TL;DR: The humoral immune response in a subset of human volunteers enrolled in a phase 1 rVSV-ZEBOV vaccination trial is examined by performing comprehensive single B cell and electron microscopy structure analyses, and highly potent EBOV-neutralizing antibodies with activities comparable or superior to the monoclonal antibodies currently used in clinical trials are detected.
Posted ContentDOI
Kinetics and Correlates of the Neutralizing Antibody Response to SARS-CoV-2
Kanika Vanshylla,Veronica Di Cristianziano,Franziska Kleipass,Felix Dewald,Philipp Schommers,Lutz Gieselmann,Henning Gruell,Maike Schlotz,Meryem S. Ercanoglu,Ricarda Stumpf,Petra Mayer,Eva Heger,Wibke Johannis,Carola Horn,Isabelle Suárez,Norma Jung,Susanne Salomon,Kirsten Eberhardt,Gerd Faetkenheuer,Nico Pfeifer,Ralf Eggeling,Max Augustin,Clara Lehmann,Florian Klein +23 more
TL;DR: A broad spectrum of the initial SARS-CoV-2 neutralizing antibody response depending on clinical characteristics is demonstrated, with antibodies being maintained in the majority of individuals for the first 10 months after mild course of COVID-19.