L
Lynette Cegelski
Researcher at Stanford University
Publications - 90
Citations - 4691
Lynette Cegelski is an academic researcher from Stanford University. The author has contributed to research in topics: Biofilm & Peptidoglycan. The author has an hindex of 30, co-authored 85 publications receiving 3928 citations. Previous affiliations of Lynette Cegelski include University of Washington & Binghamton University.
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The biology and future prospects of antivirulence therapies
TL;DR: The emergence and increasing prevalence of bacterial strains that are resistant to available antibiotics demand the discovery of new therapeutic approaches, and targeting virulence represents a new paradigm to empower the clinician to prevent and treat infectious diseases.
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Morphological plasticity as a bacterial survival strategy.
TL;DR: Bacteria have evolved complex systems to maintain consistent cell morphologies, but in certain circumstances, bacteria alter this highly regulated process to transform into filamentous organisms.
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Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation
Lynette Cegelski,Jerome S. Pinkner,Neal D. Hammer,Corinne K. Cusumano,Chia S. Hung,Erik Chorell,Veronica Åberg,Jennifer N. Walker,Patrick C. Seed,Fredrik Almqvist,Matthew George Chapman,Scott J. Hultgren +11 more
TL;DR: The ability of FN075 to block the biogenesis of both curli and type 1 pili endows unique anti-biofilm and anti-virulence activities on these compounds.
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Mechanochemical unzipping of insulating polyladderene to semiconducting polyacetylene.
Zhixing Chen,Jaron A. M. Mercer,Xiaolei Zhu,Xiaolei Zhu,Joseph A. H. Romaniuk,Raphael Pfattner,Lynette Cegelski,Todd J. Martínez,Todd J. Martínez,Noah Z. Burns,Yan Xia +10 more
TL;DR: A mechanochemically responsive nonconjugated polymer that converts to a conjugated polymer via an extensive rearrangement of the macromolecular structure in response to force is reported, based on the facile mechanochemical unzipping of polyladderene.
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Phosphoethanolamine cellulose: A naturally produced chemically modified cellulose.
Wiriya Thongsomboon,Diego O. Serra,Alexandra Possling,Chris Hadjineophytou,Chris Hadjineophytou,Regine Hengge,Lynette Cegelski +6 more
TL;DR: It is found that Escherichia coli produces chemically modified cellulose that is required for extracellular matrix assembly and biofilm architecture, and inspires efforts to biosynthetically engineer alternatively modified cellulosic materials.