M
M. Behfar Ardehali
Researcher at Harvard University
Publications - 11
Citations - 1453
M. Behfar Ardehali is an academic researcher from Harvard University. The author has contributed to research in topics: Transcription (biology) & RNA polymerase II. The author has an hindex of 9, co-authored 11 publications receiving 1295 citations. Previous affiliations of M. Behfar Ardehali include Cornell University.
Papers
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Journal ArticleDOI
Defining mechanisms that regulate RNA polymerase II transcription in vivo
TL;DR: These studies identify points in the transcription cycle where RNA polymerase II accumulates after encountering a rate-limiting step and identify key regulatory steps and factors and provide an understanding of the mechanistic generalities, as well as the rich diversities, of gene regulation.
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Drosophila Set1 is the major histone H3 lysine 4 trimethyltransferase with role in transcription
TL;DR: The data suggest that dSet1‐dependent H3K4me3 is responsible for the generation of a chromatin structure at active promoters that ensures optimal Pol II release into productive elongation.
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Spt6 enhances the elongation rate of RNA polymerase II in vivo
M. Behfar Ardehali,Jie Yao,Karen Adelman,Nicholas J. Fuda,Steven J. Petesch,Watt W. Webb,John T. Lis +6 more
TL;DR: RNAi depletion of Spt6 reveals its broad requirement during different stages of development, reducing the elongation rate from ∼1100 to 500 bp/min.
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Drosophila Paf1 modulates chromatin structure at actively transcribed genes.
Karen Adelman,Wenxiang Wei,M. Behfar Ardehali,Janis Werner,Bing Zhu,Danny Reinberg,John T. Lis +6 more
TL;DR: It is demonstrated that although Drosophila Paf1, Rtf1, and Cdc73 colocalize broadly with actively transcribing, phosphorylated Pol II, and all are recruited to activated heat shock genes with similar kinetics; RTF1 does not appear to be a stable part of the Drosophile Pf1 complex.
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Tracking rates of transcription and splicing in vivo
M. Behfar Ardehali,John T. Lis +1 more
TL;DR: The results demonstrate a rather uniform, and high, elongation rate at large human genes and co-transcriptional pre-mRNA splicing of both U2- and U12-dependent primary transcripts.