M
M J Rapoport
Researcher at University of Toronto
Publications - 4
Citations - 748
M J Rapoport is an academic researcher from University of Toronto. The author has contributed to research in topics: Tyrosine phosphorylation & T cell. The author has an hindex of 4, co-authored 4 publications receiving 742 citations.
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Journal ArticleDOI
Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice.
M J Rapoport,Andrés Jaramillo,D Zipris,Alan H. Lazarus,David V. Serreze,E H Leiter,P Cyopick,Jayne S. Danska,Terry L. Delovitch +8 more
TL;DR: The ability of rIL-4 to reverse completely the NOD thymic and peripheral T cell proliferative defect in vitro and protect against diabetes in vivo provides further support for a causal relationship between this T cell Proliferative unresponsiveness and susceptibility to diabetes in NOD mice.
Journal ArticleDOI
Thymic T cell anergy in autoimmune nonobese diabetic mice is mediated by deficient T cell receptor regulation of the pathway of p21ras activation.
TL;DR: It is shown that NOD thymic T cell anergy, as revealed by proliferative unresponsiveness in vitro after stimulation through the T cell receptor (TCR), is associated with defective TCR-mediated signal transduction along the PKC/p21ras/p42mapk pathway of T cell activation.
Journal ArticleDOI
Antigen-induced B lymphocyte activation involves the p21ras and ras.GAP signaling pathway.
TL;DR: Three novel findings are presented that demonstrate directly that AgR-mediated signaling in B cells functions by the p21ras/ras.GAP-dependent pathway.
Journal Article
Tyrosine kinase and CD45 tyrosine phosphatase activity mediate p21ras activation in B cells stimulated through the antigen receptor.
Kiyotaka Kawauchi,Alan H. Lazarus,M J Rapoport,A E Harwood,John C. Cambier,Terry L. Delovitch +5 more
TL;DR: The data indicate that p21ras activation induced by AgR cross-linking in B cells is regulated by both PTK and CD45 PTPase activities.