J
Jayne S. Danska
Researcher at University of Toronto
Publications - 90
Citations - 7531
Jayne S. Danska is an academic researcher from University of Toronto. The author has contributed to research in topics: T-cell receptor & T cell. The author has an hindex of 38, co-authored 89 publications receiving 6642 citations. Previous affiliations of Jayne S. Danska include Stanford University & Cold Spring Harbor Laboratory.
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Journal ArticleDOI
Sex Differences in the Gut Microbiome Drive Hormone-Dependent Regulation of Autoimmunity
Janet Markle,Daniel N. Frank,Steven M. Mortin-Toth,Charles E. Robertson,Leah M. Feazel,Ulrike Rolle-Kampczyk,Martin von Bergen,Kathy D. McCoy,Andrew J. Macpherson,Jayne S. Danska +9 more
TL;DR: It is demonstrated that early-life microbial exposures determine sex hormone levels and modify progression to autoimmunity in the nonobese diabetic (NOD) mouse model of type 1 diabetes (T1D), and Colonization by commensal microbes elevated serum testosterone and protected NOD males from T1D.
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Stem cell gene expression programs influence clinical outcome in human leukemia
Kolja Eppert,Katsuto Takenaka,Eric R. Lechman,Levi Waldron,Björn Nilsson,Peter van Galen,Klaus H. Metzeler,Armando G. Poeppl,Vicki Ling,Joseph Beyene,Angelo J. Canty,Jayne S. Danska,Stefan K. Bohlander,Christian Buske,Mark D. Minden,Todd R. Golub,Igor Jurisica,Benjamin L. Ebert,John E. Dick +18 more
TL;DR: It is shown that acute myeloid leukemia (AML) follows a CSC model on the basis of sorting multiple populations from each of 16 primary human AML samples and identifying which contain leukemia stem cells (LSCs) using a sensitive xenograft assay, establishing that LSCs are clinically relevant and not artifacts of xenotransplantation.
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Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice.
M J Rapoport,Andrés Jaramillo,D Zipris,Alan H. Lazarus,David V. Serreze,E H Leiter,P Cyopick,Jayne S. Danska,Terry L. Delovitch +8 more
TL;DR: The ability of rIL-4 to reverse completely the NOD thymic and peripheral T cell proliferative defect in vitro and protect against diabetes in vivo provides further support for a causal relationship between this T cell Proliferative unresponsiveness and susceptibility to diabetes in NOD mice.
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Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells
Katsuto Takenaka,Tatiana K. Prasolava,Jean C.Y. Wang,Steven M. Mortin-Toth,Sam Khalouei,Olga I. Gan,John E. Dick,John E. Dick,Jayne S. Danska +8 more
TL;DR: It is found that the NOD Sirpa allele conferred support for human hematopoiesis, and Sirpa polymorphism was identified as a potent genetic determinant of the engraftment of human heMatopoietic stem cells.
Journal ArticleDOI
V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors.
Cynthia J. Guidos,Christine J. Williams,Ildiko Grandal,G. Knowles,M. T. F. Huang,Jayne S. Danska +5 more
TL;DR: It is demonstrated that a p53-mediated DNA damage checkpoint contributes to the immune deficiency characteristic of the scid mutation and limits the oncogenic potential of DSBs generated during V(D)J recombination.