M. Ovize

TL;DR: Diastolic dysfunction diagnosed according to current recommendations is frequent in patients with DM but is also influenced by other factors, indicating that diastolics dysfunction should not be considered the first marker of a preclinical form of diabetic cardiomyopathy.

TL;DR: Diabetic patients without overt heart disease display subclinical alteration of both radial and longitudinal LV systolic function even after adjustment for blood pressure, age, and body mass index.

TL;DR: The investigators meeting at the Hatter Cardiovascular Institute workshop describe the challenge of translating strong pre-clinical data into effective clinical intervention strategies in patients in whom effective medical therapy is already altering the pathophysiology of ischaemia/reperfusion injury and lay out a clearly defined framework for future basic and clinical research to improve the chances of successful translation of strongPre-clinical interventions in man.

TL;DR: Measurement of right ventricular function by Doppler tissue imaging, an easy, noninvasive, and reproducible method, is an independent predictor of clinical outcomes in patients with severe pulmonary hypertension.

TL;DR: It is suggested that isoflurane, but not cyclosporine A, can prevent lethal reperfusion injury in this in vivo rat model and the mitochondrial calcium retention capacity significantly increased only in the Post-Iso group after succinate activation.