M
M.P. De Méo
Publications - 3
Citations - 975
M.P. De Méo is an academic researcher. The author has contributed to research in topics: Genotoxicity & Comet assay. The author has an hindex of 2, co-authored 3 publications receiving 951 citations.
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Journal ArticleDOI
The single cell gel electrophoresis assay (comet assay): A European review
Valerie J. McKelvey-Martin,Michael H.L. Green,P. Schmezer,Beatrice L. Pool-Zobel,M.P. De Méo,Andrew Collins +5 more
TL;DR: The development of the SCGE assay, existing protocols for the detection and analysis of comets, the relevant underlying principles determining the behaviour of DNA, and the potential applications of the technique are reviewed.
Journal ArticleDOI
Evaluation of the genotoxic activity of metronidazole and dimetridazole in human lymphocytes by the comet assay
J.L. Re,M.P. De Méo,Michèle Laget,H. Guiraud,Marcel Castegnaro,Patrice Vanelle,Gérard Duménil +6 more
TL;DR: It is suggested that MZ and DZ induce DNA damage in human lymphocytes through the futile cycle because the one-electron reduction of the drugs leads to the production of nitro radical anions in the presence of oxygen.
Journal ArticleDOI
Implication of nitro group reduction in the mutagenic and chromosome damaging activities of 22 new 5-nitroisoquinolines by the Salmonella mutagenicity test and the cytokinesis-blocked micronucleus assay
Thierry Orsière,M.P. De Méo,P Rathelot,J. Pompili,M Galas,Marcel Castegnaro,P Vanelle,Gérard Duménil +7 more
TL;DR: The mutagenic and chromosome-damaging activities of 22 potential antimalarial drugs (5-nitroisoquinoline derivatives) were evaluated by the Salmonella test and the cytokinesis-blocked micronucleus assay, suggesting two distinct pathways of DNA damage.