M
M Padayachee
Publications - 4
Citations - 814
M Padayachee is an academic researcher. The author has contributed to research in topics: Hyper IgM syndrome & Immunoglobulin class switching. The author has an hindex of 4, co-authored 4 publications receiving 808 citations.
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Journal ArticleDOI
Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM
Ulf Korthäuer,Daniel Graf,Hans W. Mages,Francine Brière,M Padayachee,Sue Malcolm,Alberto G. Ugazio,Luigi D. Notarangelo,Roland J. Levinsky,Richard A. Kroczek +9 more
TL;DR: Evidence is presented that point mutations in the TRAP gene give rise to nonfunctional or defective expression of TRAP on the surface of T cells in patients with HIGM1, which is responsible for the observed immunoglobulin isotype defect in HIGm1.
Journal ArticleDOI
Mapping of the X-linked form of hyper-IgM syndrome (HIGM1) to Xq26 by close linkage to HPRT.
Journal ArticleDOI
Mapping of the X linked form of hyper IgM syndrome (HIGM1)
M Padayachee,Roland J. Levinsky,Christine Kinnon,Adam Finn,C. McKeown,C. Feighery,Luigi D. Notarangelo,Rudolf W. Hendriks,A P Read,S. Malcolm +9 more
TL;DR: In this paper, the most likely position for the gene is close to HPRT with a maximum lod score of 4.89, which implies that HIGM1 is not allelic to X linked lymphoproliferative disease.
Journal ArticleDOI
Human CD40L gene maps between DXS144E and DXS300 in Xq26
Giuseppe Pilia,Giovanni Porta,M Padayachee,Sue Malcolm,Ileana Zucchi,Anna Villa,Paolo Macchi,Paolo Vezzoni,David Schlessinger +8 more
TL;DR: PCR primers for the 3{prime} end of the CD40L gene, were used to screen the YACs in the Xq26 contig.