M
M Valappil
Researcher at Newcastle upon Tyne Hospitals NHS Foundation Trust
Publications - 31
Citations - 1216
M Valappil is an academic researcher from Newcastle upon Tyne Hospitals NHS Foundation Trust. The author has contributed to research in topics: HBsAg & Hepatitis B virus. The author has an hindex of 15, co-authored 31 publications receiving 1020 citations. Previous affiliations of M Valappil include Royal Victoria Infirmary & Health Protection Agency.
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Journal ArticleDOI
British HIV Association guidelines for the routine investigation and monitoring of adult HIV‐1‐infected individuals 2011
David Asboe,C Aitken,Marta Boffito,Clare Booth,Patricia A. Cane,Ade Fakoya,Anna Maria Geretti,Peter Kelleher,Nicola Mackie,D Muir,Gary Murphy,Chloe Orkin,Frank A. Post,G Rooney,Caroline A. Sabin,Lorraine Sherr,Erasmus Smit,W Tong,A Ustianowski,M Valappil,J Walsh,Matthew Williams,D Yirrell +22 more
TL;DR: This review concludes that routine monitoring on ART for HIV‐infected patients and individuals transferring care from a different HIV healthcare setting is a viable option and should be considered.
Journal ArticleDOI
STAT2 deficiency and susceptibility to viral illness in humans
Sophie Hambleton,Stephen Goodbourn,Dan F. Young,Paul Dickinson,Siti Mardhiana Mohamad,Siti Mardhiana Mohamad,M Valappil,Naomi McGovern,Andrew J. Cant,Andrew J. Cant,Scott Hackett,Peter Ghazal,Neil V. Morgan,Richard E. Randall +13 more
TL;DR: The findings imply that type I IFN signaling [through interferon-stimulated gene factor 3 (ISGF3)] is surprisingly not essential for host defense against the majority of common childhood viral infections.
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Human IFNAR2 deficiency : lessons for antiviral immunity
Christopher J A Duncan,Christopher J A Duncan,Siti Mardhiana Mohamad,Siti Mardhiana Mohamad,Dan F. Young,Andrew J. Skelton,T. Ronan Leahy,Diane C. Munday,Karina Butler,Sofia Morfopoulou,Julianne R Brown,Julianne R Brown,Mike Hubank,Jeff Connell,Patrick J. Gavin,Cathy McMahon,Eugene M. Dempsey,Niamh E. Lynch,Thomas S. Jacques,M Valappil,Andrew J. Cant,Andrew J. Cant,Judith Breuer,Judith Breuer,Karin R. Engelhardt,Richard E. Randall,Sophie Hambleton,Sophie Hambleton +27 more
TL;DR: The phenotype of IFNAR2 deficiency, together with similar findings in STAT2-deficient patients, supports an essential but narrow role for IFN-α/β in human antiviral immunity.
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Influenza A/H1N1v in pregnancy: an investigation of the characteristics and management of affected women and the relationship to pregnancy outcomes for mother and infant.
Laura Yates,Matthias Pierce,Sally Stephens,Aileen C. Mill,Patsy Spark,Jennifer J Kurinczuk,M Valappil,Peter Brocklehurst,Simon H. L. Thomas,Marian Knight +9 more
TL;DR: Assessment of rates of and risk factors for adverse outcomes following AH1N1v infection in pregnancy and the adverse effects of the antiviral drugs and vaccines used in prevention and management found earlier treatment with antiviral agents is associated with improved outcomes for pregnant women.
Journal ArticleDOI
Hepatitis B in pregnancy
Jessica K Dyson,Julia Waller,Andrena Turley,Enid Michael,S.E. Moses,M Valappil,Mark Hudson,Margaret Bassendine,Stuart McPherson +8 more
TL;DR: One in six women had active HBV requiring treatment or high HBV-DNA levels that would benefit from antiviral treatment to reduce the transmission risk.