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Naomi McGovern
Researcher at University of Cambridge
Publications - 52
Citations - 6738
Naomi McGovern is an academic researcher from University of Cambridge. The author has contributed to research in topics: Population & Immune system. The author has an hindex of 25, co-authored 50 publications receiving 5628 citations. Previous affiliations of Naomi McGovern include Newcastle University & Singapore Immunology Network.
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Journal ArticleDOI
IRF4 Transcription Factor-Dependent CD11b+ Dendritic Cells in Human and Mouse Control Mucosal IL-17 Cytokine Responses
Andreas Schlitzer,Naomi McGovern,Pearline Teo,Teresa Zelante,Koji Atarashi,Donovan Low,Adrian W. S. Ho,Peter See,Amanda Shin,Pavandip Singh Wasan,Guillaume Hoeffel,Benoit Malleret,Alexander F. Heiseke,Samantha Chew,Laura Jardine,Harriet A. Purvis,Catharien M. U. Hilkens,John Kit Chung Tam,Michael Poidinger,E. Richard Stanley,Anne Krug,Laurent Rénia,Baalasubramanian Sivasankar,Lai Guan Ng,Matthew Collin,Paola Ricciardi-Castagnoli,Kenya Honda,Muzlifah Haniffa,Florent Ginhoux +28 more
TL;DR: The demonstration of mouse and human DC subsets specialized in driving IL-17 responses highlights the conservation of key immune functions across species and will facilitate the translation of mouse in vivo findings to advance DC-based clinical therapies.
Journal ArticleDOI
Human Tissues Contain CD141hi Cross-Presenting Dendritic Cells with Functional Homology to Mouse CD103+ Nonlymphoid Dendritic Cells
Muzlifah Haniffa,Muzlifah Haniffa,Amanda Shin,Venetia Bigley,Naomi McGovern,Pearline Teo,Peter See,Pavandip Singh Wasan,Xiao-Nong Wang,Frano Malinarich,Benoit Malleret,Anis Larbi,Pearlie W.W. Tan,Helen Zhao,Michael Poidinger,Sarah Pagan,Sharon Cookson,Rachel E. Dickinson,Ian Dimmick,Ruth F. Jarrett,Laurent Rénia,John Siu-Lun Tam,Colin Song,John E. Connolly,Jerry Kok Yen Chan,Jerry Kok Yen Chan,Adam J. Gehring,Antonio Bertoletti,Matthew Collin,Florent Ginhoux +29 more
TL;DR: A CD141hi DC present in human interstitial dermis, liver, and lung that was distinct from the majority of CD1c+ and CD14+ tissue DCs and superior at cross-presenting soluble antigens was identified.
Journal ArticleDOI
Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species.
Martin Guilliams,Martin Guilliams,Charles-Antoine Dutertre,Charles-Antoine Dutertre,Charlotte L. Scott,Naomi McGovern,Dorine Sichien,Svetoslav Chakarov,Sofie Van Gassen,Jinmiao Chen,Michael Poidinger,Sofie De Prijck,Simon Tavernier,Ivy Low,Sergio Erdal Irac,Citra Nurfarah Zaini Mattar,Hermi Sumatoh,Gillian Low,Tam John Kit Chung,Dedrick Kok Hong Chan,Ker-Kan Tan,Tony Lim Kiat Hon,Even Fossum,Bjarne Bogen,Mahesh Choolani,Jerry Kok Yen Chan,Anis Larbi,Hervé Luche,Sandrine Henri,Yvan Saeys,Evan W. Newell,Bart N. Lambrecht,Bart N. Lambrecht,Bernard Malissen,Florent Ginhoux +34 more
TL;DR: A universal toolbox for the automated identification of DCs through unsupervised analysis of conventional flow cytometry and mass cytometry data obtained from multiple mouse, macaque, and human tissues is provided and validated.
Journal ArticleDOI
Human dendritic cell subsets.
TL;DR: Comparative studies are now allowing many of these properties of Dendritic cells to be more fully understood in the context of human immunology.
Journal ArticleDOI
Mapping the human DC lineage through the integration of high-dimensional techniques
Peter See,Charles-Antoine Dutertre,Charles-Antoine Dutertre,Jinmiao Chen,Patrick Günther,Naomi McGovern,Sergio Erdal Irac,Merry Gunawan,Marc Beyer,Marc Beyer,Kristian Händler,Kaibo Duan,Hermi Sumatoh,Nicolas Ruffin,Mabel Jouve,Ester Gea-Mallorquí,Raoul C.M. Hennekam,Tony Kiat Hon Lim,Chan Chung Yip,Ming Wen,Benoit Malleret,Benoit Malleret,Ivy Low,Nurhidaya Binte Shadan,Charlene Foong Shu Fen,Alicia Tay,Josephine Lum,Francesca Zolezzi,Anis Larbi,Michael Poidinger,Jerry Kok Yen Chan,Qingfeng Chen,Laurent Rénia,Muzlifah Haniffa,Philippe Benaroch,Andreas Schlitzer,Andreas Schlitzer,Joachim L. Schultze,Joachim L. Schultze,Evan W. Newell,Florent Ginhoux +40 more
TL;DR: Two unbiased high-dimensional technologies are employed to characterize the human DC lineage from bone marrow to blood and provide new markers that can be used to identify unambiguously pre-DC from pDC, including CD33, CX3CR1, CD2, CD5, and CD327.