M
Mike Hubank
Researcher at The Royal Marsden NHS Foundation Trust
Publications - 169
Citations - 9507
Mike Hubank is an academic researcher from The Royal Marsden NHS Foundation Trust. The author has contributed to research in topics: Gene & Gene expression profiling. The author has an hindex of 47, co-authored 154 publications receiving 7877 citations. Previous affiliations of Mike Hubank include UCL Institute of Neurology & Boston Children's Hospital.
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Journal ArticleDOI
Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients
Steven J. Howe,Marc R. Mansour,Kerstin Schwarzwaelder,Cynthia C. Bartholomae,Mike Hubank,Helena Kempski,Martijn H. Brugman,Karin Pike-Overzet,S Chatters,Dick de Ridder,Dick de Ridder,Kimberly Gilmour,Stuart Adams,Susannah I. Thornhill,Kathryn L. Parsley,Frank J. T. Staal,Rosemary E. Gale,David C. Linch,Jinhua Bayford,Lucie Brown,Michelle Quaye,Christine Kinnon,Philip Ancliff,David Webb,Manfred Schmidt,Christof von Kalle,H. Bobby Gaspar,Adrian J. Thrasher +27 more
TL;DR: The occurrence of clonal T cell acute lymphoblastic leukemia (T-ALL) promoted by insertional mutagenesis in a completed gene therapy trial of 10 SCID-X1 patients is described and a general toxicity of endogenous gammaretroviral enhancer elements is highlighted.
Journal ArticleDOI
Epilepsy, ataxia, sensorineural deafness, tubulopathy, and KCNJ10 mutations.
Detlef Bockenhauer,Sally Feather,Horia Stanescu,Sascha Bandulik,Anselm A. Zdebik,Markus Reichold,Jonathan Tobin,E Lieberer,Christina Sterner,Guida Landouré,Ruchi Arora,Tony Sirimanna,Dorothy A. Thompson,J. Helen Cross,William van’t Hoff,Omar Al Masri,Kjell Tullus,Stella Yeung,Yair Anikster,Enriko Klootwijk,Mike Hubank,Michael J. Dillon,Dirk Heitzmann,Mauricio Arcos-Burgos,Mark A Knepper,Angus Dobbie,William A. Gahl,Richard Warth,Eamonn Sheridan,Robert Kleta +29 more
TL;DR: In this paper, the authors investigated the genetic basis of this autosomal recessive disease, which they call the EAST syndrome (the presence of epilepsy, ataxia, sensorineural deafness, and tubulopathy).
Journal ArticleDOI
Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy
Horia Stanescu,Mauricio Arcos-Burgos,Alan Medlar,Detlef Bockenhauer,Anna Köttgen,L. Dragomirescu,C. Voinescu,N. Patel,K. Pearce,Mike Hubank,H.A.F. Stephens,V. Laundy,Sandosh Padmanabhan,A. Zawadzka,Julia M. Hofstra,Marieke J H Coenen,M. den Heijer,Lambertus A. Kiemeney,D. Bacq-Daian,Bénédicte Stengel,S. H. Powis,Paul Brenchley,J. Feehally,Andrew J. Rees,Hanna Debiec,Jack F.M. Wetzels,Pierre Ronco,Peter W. Mathieson,Robert Kleta +28 more
TL;DR: An HLA-DQA1 allele on chromosome 6p21 is most closely associated with idiopathic membranous nephropathy in persons of white ancestry and may facilitate an autoimmune response against targets such as variants of PLA2R1.
Journal ArticleDOI
Photoreceptor precursors derived from three-dimensional embryonic stem cell cultures integrate and mature within adult degenerate retina
Anai Gonzalez-Cordero,Emma L. West,Rachael A. Pearson,Yanai Duran,Livia S. Carvalho,Colin J Chu,Arifa Naeem,Samuel J.I. Blackford,Anastasios Georgiadis,Jorn Lakowski,Mike Hubank,Alexander J. Smith,James W B Bainbridge,Jane C. Sowden,Robin R. Ali,Robin R. Ali +15 more
TL;DR: This study shows conclusively that ESCs can provide a source of photoreceptors for retinal cell transplantation and adapted a recently reported three-dimensional differentiation protocol that generates neuroretina from mouse ESCs to isolate photoreceptor precursors fit for transplantation.
Journal ArticleDOI
Same Exposure but Two Radically Different Responses to Antibiotics: Resilience of the Salivary Microbiome versus Long-Term Microbial Shifts in Feces
Egija Zaura,Bernd W. Brandt,M. Joost Teixeira de Mattos,Mark J. Buijs,Martien P. M. Caspers,Mamun-Ur Rashid,Andrej Weintraub,Carl Erik Nord,Ann Savell,Yanmin Hu,Antony R. Coates,Mike Hubank,David A. Spratt,Michael Wilson,Bart J. F. Keijser,Wim Crielaard +15 more
TL;DR: Healthy individuals, exposed to a single antibiotic treatment, undergo considerable microbial shifts and enrichment in antibiotic resistance in their feces, while their salivary microbiome composition remains unexpectedly stable.