M
Maciej Masłyk
Researcher at John Paul II Catholic University of Lublin
Publications - 58
Citations - 972
Maciej Masłyk is an academic researcher from John Paul II Catholic University of Lublin. The author has contributed to research in topics: Steroid sulfatase & Candida albicans. The author has an hindex of 15, co-authored 50 publications receiving 602 citations. Previous affiliations of Maciej Masłyk include The Catholic University of America & CEU San Pablo University.
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Journal ArticleDOI
Steroid Sulfatase Inhibitors Based on Phosphate and Thiophosphate Flavone Analogs
TL;DR: A series of phosphate and thiophosphate flavone derivatives were synthesized and biologically evaluated in vitro for inhibition of steroid sulfatase (STS) activity.
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Multisite-directed inhibitors of protein kinase CK2: new challenges
Robert Świder,Robert Świder,Maciej Masłyk,Maciej Masłyk,Sonsoles Martín-Santamaría,Ana Ramos,Beatriz de Pascual-Teresa +6 more
TL;DR: Docking studies allowed us to identify key interactions between CK2 and the designed ligands, which will be useful to optimize this series of multisite-directed inhibitors.
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CX-4945: the protein kinase CK2 inhibitor and anti-cancer drug shows anti-fungal activity.
TL;DR: The presented data reveal the influence of CX-4945 on the growth of yeast cells showing variable potency against Saccharomyces cerevisiae deletion strains with different contents of CK2 subunits, and the catalytic subunit CK2α appears to sensitize yeast to the CX -4945 action.
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AD-O53.2—a novel recombinant fusion protein combining the activities of TRAIL/Apo2L and Smac/Diablo, overcomes resistance of human cancer cells to TRAIL/Apo2L
Jerzy Pieczykolan,Konrad Kubiński,Maciej Masłyk,Sebastian Pawlak,Anna Pieczykolan,Piotr Rózga,Michal Szymanik,Marlena Gałązka,Malgorzata Teska-Kaminska,Bartłomiej Żerek,Katarzyna Bukato,Katarzyna Poleszak,Albert Jaworski,Wojciech Strozek,Robert Świder,Rafal Zielinski +15 more
TL;DR: A recombinant variant of TRAIL\Apo2L peptide fused to the peptide-derived from Smac/Diablo protein—the natural inhibitor of the apoptotic X-linked IAP (XIAP) protein considered as a pro-apoptotic agent that significantly reduced the rate of the tumor growth in colon and lung adenocarcinoma animal models.
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In Search of the Antimicrobial Potential of Benzimidazole Derivatives.
Monika Janeczko,Zygmunt Kazimierczuk,Andrzej Orzeszko,Andrzej Niewiadomy,Ewa Król,Ryszard Szyszka,Maciej Masłyk +6 more
TL;DR: A broad series of 4,5,6,7-tetrahalogenated benzimidazoles and 4-(1H-benzimidAZol-2-yl)-benzene-1,3-diol derivatives was tested against selected bacteria and fungi and only 8, 16, 18 and 19 showed moderate to good inhibition against bacterial strains.