S
Sebastian Demkowicz
Researcher at Gdańsk University of Technology
Publications - 40
Citations - 557
Sebastian Demkowicz is an academic researcher from Gdańsk University of Technology. The author has contributed to research in topics: Steroid sulfatase & Chemistry. The author has an hindex of 10, co-authored 35 publications receiving 361 citations. Previous affiliations of Sebastian Demkowicz include University of Gdańsk.
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Selected organophosphorus compounds with biological activity. Applications in medicine
TL;DR: An overview of the latest applications of organophosphorus compounds (OPs) that exhibit biological activity can be found in this article, where the authors outline the findings of a literature review on OPs, including anticancer and antiviral agents, bisphosphonates, phosphorus analogues of amino acids and peptides.
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Novel 1,2,4-Oxadiazole Derivatives in Drug Discovery
TL;DR: A comprehensive overview of the recent achievements in the synthesis of 1,2,4-oxadiazole-based compounds and the major advances in their biological applications in the period of the last five years is presented as well as brief remarks on prospects for further development.
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Taurine as a water structure breaker and protein stabilizer
Piotr Bruździak,Aneta Panuszko,Emilia Kaczkowska,Barnaba Piotrowski,Anna Daghir,Sebastian Demkowicz,Janusz Stangret +6 more
TL;DR: FTIR spectroscopy, DSC calorimetry and DFT calculations are combined to gain an insight into the interactions between osmolytes and two proteins: lysozyme and ubiquitin.
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Selected Organophosphorus Compounds with Biological Activity. Applications in Medicine
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Synthesis and biological evaluation of fluorinated N-benzoyl and N-phenylacetoyl derivatives of 3-(4-aminophenyl)-coumarin-7-O-sulfamate as steroid sulfatase inhibitors.
Mateusz Daśko,Maja Przybyłowska,Janusz Rachon,Maciej Masłyk,Konrad Kubiński,Majus Misiak,Andrzej Skladanowski,Sebastian Demkowicz +7 more
TL;DR: Approximate methods for the synthesis of 3-(4-aminophenyl)-coumarin-7-O-sulfamate derivatives N-acylated with fluorinated analogues of benzoic or phenylacetic acid as steroid sulfatase (STS) inhibitors proved to selectively inhibit the growth of ER- and PR-positive cell lines.