M
Madan G. Luthra
Researcher at University of Texas MD Anderson Cancer Center
Publications - 12
Citations - 881
Madan G. Luthra is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Cancer & Gene. The author has an hindex of 9, co-authored 12 publications receiving 828 citations. Previous affiliations of Madan G. Luthra include University of Texas Health Science Center at Houston.
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Journal ArticleDOI
MicroRNA-196a targets annexin A1: a microRNA-mediated mechanism of annexin A1 downregulation in cancers
Rajyalakshmi Luthra,Rajesh R. Singh,Madan G. Luthra,Yisheng Li,Christina Hannah,Angela Romans,Bedia A. Barkoh,Su S. Chen,Joe Ensor,Dipen M. Maru,Russell Broaddus,Asif Rashid,Constance Albarracin +12 more
TL;DR: A novel mechanism of post-transcriptional regulation of ANXA1 expression is demonstrated and miR-196a is identified as a marker of esophageal cancer and suggested its oncogenic potential.
Journal ArticleDOI
Gene Expression Profiling of Localized Esophageal Carcinomas: Association With Pathologic Response to Preoperative Chemoradiation
Rajyalakshmi Luthra,Tsung Teh Wu,Madan G. Luthra,Julie G. Izzo,Enrique Lopez-Alvarez,Li Zhang,Jaime Bailey,Jeffrey H. Lee,Robert S. Bresalier,Asif Rashid,Stephen G. Swisher,Jaffer A. Ajani +11 more
TL;DR: Encouraging, albeit preliminary, data suggest that expression profiling may distinguish cancers with different pathologic outcome, and is the first report to show subtypes of esophageal cancers with distinct molecular signatures.
Journal ArticleDOI
Correlation of mutation profile and response in patients with myelofibrosis treated with ruxolitinib
Keyur P. Patel,Kate J. Newberry,Rajyalakshmi Luthra,Elias Jabbour,Sherry Pierce,Jorge E. Cortes,Rajesh R. Singh,Meenakshi Mehrotra,Mark J. Routbort,Madan G. Luthra,Taghi Manshouri,Fabio P.S. Santos,Hagop M. Kantarjian,Srdan Verstovsek +13 more
TL;DR: Target next-generation sequencing of a panel of 28 genes recurrently mutated in hematologic malignancies in a cohort of patients with myelofibrosis found that multigene profiling may be useful for therapeutic planning for MF, and patients with ≥3 mutations had the worst outcomes.
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MicroRNA-196a Is a Potential Marker of Progression during Barrett's Metaplasia-Dysplasia-Invasive Adenocarcinoma Sequence in Esophagus
Dipen M. Maru,Rajesh R. Singh,Christina Hannah,Constance Albarracin,Yong Li,Ronald Abraham,Angela Romans,Hui Yao,Madan G. Luthra,Sharmila Anandasabapathy,Stephen G. Swisher,Wayne L. Hofstetter,Asif Rashid,Rajyalakshmi Luthra +13 more
TL;DR: This study evaluated the correlation of miR-196a with its in silico-predicted targets, keratin 5 (KRT5), small proline-rich protein 2C (SPRR2C), and S100 calcium-binding protein A9 (S100A9), which are down-regulated during BE progression.
Journal ArticleDOI
Decreased expression of gene cluster at chromosome 1q21 defines molecular subgroups of chemoradiotherapy response in esophageal cancers
Madan G. Luthra,Madan G. Luthra,Jaffer A. Ajani,Julie G. Izzo,Joe Ensor,Tsung Teh Wu,Asif Rashid,Li Zhang,Alexandria T. Phan,Norio Fukami,Rajyalakshmi Luthra +10 more
TL;DR: The expression levels of genes mapping within and close to the EDC define CTXRT response subgroups in EACs, and patients in sub group I had longer survival than those in subgroup II, although this result was not statistically significant owing to the small study number.