Recent Advances in the Friedländer Reaction

Metal-Free Multicomponent Syntheses of Pyridines

A decade update on solvent and catalyst-free neat organic reactions: a step forward towards sustainability

The tert-butyl group is a common motif in medicinal chemistry. Its incorporation into bioactive compounds is often accompanied by unwanted property modulation, such as increased lipophilicity and decreased metabolic stability. Several alternative substituents are available for the drug discovery process. Herein, physicochemical data of two series of drug analogues of bosentan and vercirnon are documented as part of a comparative study of tert-butyl, pentafluorosulfanyl, trifluoromethyl, bicyclo[1.1.1]pentanyl, and cyclopropyl-trifluoromethyl substituents.

Evaluation of tert-Butyl Isosteres: Case Studies of Physicochemical and Pharmacokinetic Properties, Efficacies, and Activities

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"Recycling" classical drugs for malaria.

Friedländer condensation of 5‐aminopyrazole‐4‐carbaldehydes with reactive α‐methylene ketones: Synthesis of pyrazolo[3,4‐b]pyridines

A convenient route for the synthesis of pyrazolo[3,4‐d]pyrimidine, pyrazolo[3,4‐b][1,6]naphthyridine and pyrazolo[3,4‐b]quinoline derivatives

Synthesis of pyrazolo‐annelated heterocyclic ring compounds such as pyrazolo[3,4‐b]pyridines and pyrazolo[4′,3′:5,6]‐pyrido[2,3‐d]pyrimidines

Synthesis of pyrazolopyridine 3-carboxylates by Friedlander condensation

New one‐step synthesis of pyrazolo[1,5‐a]pyrimidine and pyrazolo[1,5‐a]quinazoline derivatives via multicomponent reactions

Madhukar N. Jachak

Papers

Friedländer condensation of 5‐aminopyrazole‐4‐carbaldehydes with reactive α‐methylene ketones: Synthesis of pyrazolo[3,4‐b]pyridines

A convenient route for the synthesis of pyrazolo[3,4‐d]pyrimidine, pyrazolo[3,4‐b][1,6]naphthyridine and pyrazolo[3,4‐b]quinoline derivatives

Synthesis of pyrazolo‐annelated heterocyclic ring compounds such as pyrazolo[3,4‐b]pyridines and pyrazolo[4′,3′:5,6]‐pyrido[2,3‐d]pyrimidines

Synthesis of pyrazolopyridine 3-carboxylates by Friedlander condensation

New one‐step synthesis of pyrazolo[1,5‐a]pyrimidine and pyrazolo[1,5‐a]quinazoline derivatives via multicomponent reactions