M
Magda L. Atilano
Researcher at University of Oxford
Publications - 21
Citations - 828
Magda L. Atilano is an academic researcher from University of Oxford. The author has contributed to research in topics: Peptidoglycan & Biology. The author has an hindex of 9, co-authored 15 publications receiving 679 citations. Previous affiliations of Magda L. Atilano include Universidade Nova de Lisboa & UCL Institute of Neurology.
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Journal ArticleDOI
Teichoic acids are temporal and spatial regulators of peptidoglycan cross-linking in Staphylococcus aureus.
Magda L. Atilano,Pedro M. Pereira,James Yates,Patricia Reed,Helena Veiga,Mariana G. Pinho,Sergio R. Filipe +6 more
TL;DR: It is found that wall teichoic acids, glycopolymers attached to the peptidoglycan and important for virulence in Gram-positive bacteria, act as temporal and spatial regulators of PGN metabolism, controlling the level of cross-linking by regulating PBP4 localization.
Journal ArticleDOI
Sensing of Gram-positive bacteria in Drosophila: GNBP1 is needed to process and present peptidoglycan to PGRP-SA.
TL;DR: A model whereby GNBP1 presents a processed form of PG for sensing by PGRP‐SA is proposed and that a tripartite interaction between these proteins and PG is essential for downstream signaling is proposed.
Journal ArticleDOI
C9orf72 arginine-rich dipeptide proteins interact with ribosomal proteins in vivo to induce a toxic translational arrest that is rescued by eIF1A.
Thomas G. Moens,Teresa Niccoli,Katherine M. Wilson,Magda L. Atilano,Nicol Birsa,Lauren M. Gittings,Benedikt V. Holbling,Miranda C. Dyson,Annora Thoeng,Jacob Neeves,Idoia Glaria,Lu Yu,Julia Bussmann,Erik Storkebaum,Erik Storkebaum,Erik Storkebaum,Mercedes Pardo,Mercedes Pardo,Jyoti S. Choudhary,Jyoti S. Choudhary,Pietro Fratta,Linda Partridge,Adrian M. Isaacs +22 more
TL;DR: expression of the translation initiation factor eIF1A uniquely rescued DPR-induced toxicity in vivo, indicating that restoring translation is a potential therapeutic strategy and directly implicate translational repression in C9orf72 repeat-induced neurodegeneration.
Journal ArticleDOI
Staphylococcus aureus Survives with a Minimal Peptidoglycan Synthesis Machine but Sacrifices Virulence and Antibiotic Resistance
Patricia Reed,Magda L. Atilano,Renato J. Alves,Egbert Hoiczyk,Xinwei Sher,Nathalie T. Reichmann,Pedro M. Pereira,Terry Roemer,Sergio Joaquim Filipe,José B. Pereira-Leal,Petros Ligoxygakis,Mariana Luisa Pinho +11 more
TL;DR: The fact that S. aureus can grow and divide with only two active PG synthesizing enzymes shows that most of these enzymes are redundant in vitro and identifies the minimal PG synthesis machinery of S.aureus.
Journal ArticleDOI
L-Rhamnosylation of Listeria monocytogenes Wall Teichoic Acids Promotes Resistance to Antimicrobial Peptides by Delaying Interaction with the Membrane.
Filipe Carvalho,Magda L. Atilano,Rita Pombinho,Gonçalo Covas,Richard L. Gallo,Sergio Joaquim Filipe,Sandra Maria Zákia Lian Sousa,Didier Cabanes +7 more
TL;DR: It is proposed that WTA L-rhamnosylation promotes L. monocytogenes survival by decreasing the cell wall permeability to AMPs, thus hindering their access and detrimental interaction with the plasma membrane, a novel link between WTA glycosylation and bacterial resistance to host defense peptides.