M
Mahaboobkhan Rasool
Researcher at VIT University
Publications - 95
Citations - 2892
Mahaboobkhan Rasool is an academic researcher from VIT University. The author has contributed to research in topics: Arthritis & RANKL. The author has an hindex of 28, co-authored 88 publications receiving 2297 citations. Previous affiliations of Mahaboobkhan Rasool include University of Madras & Management and Science University.
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Targeting RAW 264.7 macrophages (M1 type) with Withaferin-A decorated mannosylated liposomes induces repolarization via downregulation of NF-κB and controlled elevation of STAT-3.
TL;DR: It was found that successful internalization of WA via mannosylated liposomal delivery system (ML‐WA) reduced the RAW 264.7 macrophage mediated pro‐inflammatory cytokines and induced an anti‐inflammatory response by repolarizing the M1 → M2 macrophages.
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Berberine modulates ASK1 signaling mediated through TLR4/TRAF2 via upregulation of miR-23a.
TL;DR: The current findings predict that BBR is a potential candidate for therapeutic targeting of TLR4/TRAF2 mediated ASK1 activation in inflammatory and in RA pathogenesis possibly through post‐transcriptional gene silencing via upregulation of miR‐23a.
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Ferulic acid inhibits interleukin 17-dependent expression of nodal pathogenic mediators in fibroblast-like synoviocytes of rheumatoid arthritis.
TL;DR: FA is shown to be a potential therapeutic agent for inhibiting IL‐17‐mediated disease severity and bone erosion in RA and the molecular docking analysis revealed that FA manifests significant ligand efficiency toward IL‐ 17RA, STAT‐3, IL‐23, and RANKL proteins.
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Majoon ushba, a polyherbal compound, suppresses pro-inflammatory mediators and RANKL expression via modulating NFкB and MAPKs signaling pathways in fibroblast-like synoviocytes from adjuvant-induced arthritic rats.
TL;DR: Evidence is provided that MU possesses anti-inflammatory effect against AIA-FLS through the decrease in pro-inflammatory mediators expression by suppressing NFкB and MAPKs signaling pathways.
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Hepatoprotective and antioxidant potential of ferulic acid against acetaminophen-induced liver damage in mice
Dhanalakshmi Navaneetha Krishnan,Nagalakshmi Prasanna,Evan Prince Sabina,Mahaboobkhan Rasool +3 more
TL;DR: Results clearly exhibit that ferulic acid possesses promising hepatoprotective potential against acetaminophen-induced liver damage in mice and significantly reverse the above-mentioned changes similar to the positive drug silymarin.