M
Mahboobeh Nazari
Researcher at Avicenna Research Institute
Publications - 57
Citations - 852
Mahboobeh Nazari is an academic researcher from Avicenna Research Institute. The author has contributed to research in topics: Luciferase & Gene delivery. The author has an hindex of 15, co-authored 49 publications receiving 626 citations. Previous affiliations of Mahboobeh Nazari include Academic Center for Education, Culture and Research & Tarbiat Modares University.
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Mosaicism in CRISPR/Cas9-mediated genome editing
TL;DR: By developing ways to overcome mosaic mutations when usingCRISPR/Cas9, genotyping for germline gene disruptions should become more reliable and pave the way for using the CRISPR technology in the research and clinical applications where mosaicism is an issue.
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Immobilization of laccase on epoxy-functionalized silica and its application in biodegradation of phenolic compounds.
Mehdi Mohammadi,Mohammad Ali As’habi,Peyman Salehi,Maryam Yousefi,Mahboobeh Nazari,Jesper Brask +5 more
TL;DR: The immobilized enzyme was found to be stabilized compared to the free enzyme, and the performance of the biocatalyst was evaluated by the degradation of phenolic compounds including phenol, p-chlorophenol and catechol.
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Design and introduction of a disulfide bridge in firefly luciferase: increase of thermostability and decrease of pH sensitivity
TL;DR: Thermal denaturation analysis showed that conformational stabilities of A103C/S121C and A296C/A326C are more than native firefly luciferase, and the formation of a disulfide bridge in this region has more impact on enzyme kinetic characteristics.
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Design of disulfide bridge as an alternative mechanism for color shift in firefly luciferase and development of secreted luciferase
TL;DR: It is proposed that the stability of a protein can be increased by introduction of disulfide bridge that decreases the configurational entropy of unfolding and this might make mutant luciferase suitable reporters for the study of gene expression in high through-put screening.
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Novel chitosan based nanoparticles as gene delivery systems to cancerous and noncancerous cells.
Soheila Rahmani,Shirin Hakimi,Azam Esmaeily,Fatemeh Samadi,Elaheh Mortazavian,Mahboobeh Nazari,Zohreh Mohammadi,Zohreh Mohammadi,Niyousha Rafiee Tehrani,Morteza Rafiee Tehrani +9 more
TL;DR: It is indicated that chemical structure of these novel chitosan derivatives in the interaction with the cell type can lead to successful gene delivery.