A comprehensive review in current developments of benzothiazole-based molecules in medicinal chemistry.

Heterocycles bearing nitrogen, sulphur and thiazole moieties constitute the core structure of a number of biologically interesting compounds. Benzothiazole, a group of xenobiotic compounds containing a benzene ring fused with a thiazole ring, are used worldwide for a variety of therapeutic applications. Benzothiazole and their heterocyclic derivatives represent an important class of compounds possessing a wide spectrum of biological activities. The myriad spectrum of medicinal properties associated with benzothiazole related drugs has encouraged the medicinal chemists to synthesize a large number of novel therapeutic agents. Several analogues containing benzothiazole ring system exhibit significant antitumour, antimicrobial, antidiabetic, anti-inflammatory, anticonvulsant, antiviral, antioxidant, antitubercular, antimalarial, antiasthmatic, anthelmintic, photosensitizing, diuretic, analgesic and other activities. This article is an attempt to present the research work reported in recent scientific literat...

https://www.tandfonline.com/doi/pdf/10.3109/14756366.2012.720572

Medicinal significance of benzothiazole scaffold: an insight view

Benzimidazoles: A biologically active compounds

Benzothiazole is a privileged heterocyclic scaffold having a benzene ring fused with a five-membered thiazole ring. This moiety has attracted considerable attention because of its wide range of pharmacological activities such as antitubercular, antimicrobial, antimalarial, anticonvulsant, anthelmintic, analgesic, anti-inflammatory, antidiabetic, antitumor activity, etc. In the last few years, some novel benzothiazoles have been developed with varied biological activities. To access this scaffold in high yield and to introduce diversity, a variety of new synthetic methods have been invented. In this review, we highlight the development of novel benzothiazoles for various biological activities along with the best synthetic protocols for their synthesis.

http://www.chtf.stuba.sk/~szolcsanyi/education/files/Chemia%20heterocyklickych%20zlucenin/Prednaska%203/Doplnkove%20studijne%20materialy/Di-Azoles/Recent%20Advances%20in%20the%20Chemistry%20and%20Biology%20of%20Benzothiazoles.pdf

Recent Advances in the Chemistry and Biology of Benzothiazoles

Heterocyclic 1,2,4-triazole derivatives possess unusually spacious potentiality as medicinal agents, agricultural chemicals, functional materials, ionic liquids, supramolecular catalysts as well as artificial enzymes and receptors for supramolecular recognition and biomimetic catalysis, and their various researches and developments have been being a quite rapidly developing and active highlight topic with an infinite space. Numerous efforts have been directed toward various types of possible applications of 1,2,4-triazole-based compounds and a lot of important progress has been made, especially their preparations have attracted increasing attention. This review systematically summarized the recent advances in the syntheses of 1,2,4-triazole derivatives, including: (1) Cyclizations to form triazole ring; (2) Transformations of heterocyclic compounds to construct triazole ring; (3) Substitutions on 1,2,4-triazole ring; (4) Structural modifications in side chains of 1,2,4-triazole ring. It was hoped that this review would be helpful for the design and development of highly efficient preparation of 1,2,4-triazole derivatives with various sorts and varieties of extensively potential applications in medicine, agriculture, chemistry, materials, supramolecular sciences and so on.

Current Developments in the Syntheses of 1,2,4-Triazole Compounds

Synthesis and evaluation of some new benzothiazole derivatives as potential antimicrobial agents.

One of the most important goals in medicinal chemistry is the development of new heterocyclic compounds with antitumor activity. Thus, a novel series of Schiff bases 1-11, the derivatives of 2-aryl1H-benzimidazole has been synthesized and evaluated for their cytotoxic activity against the cells of human cancer cell lines, namely K-562 (myelogenous leukemia) and HL-60 (promyelocytic leukemia). Among the compounds tested against K-562 cell line, compounds 1, 7 and 10 showed potent activity and the compound 5 exhibited better activity against HL-60 cell line.

Original Research Paper SYNTHESIS AND IN VITRO ANTITUMOR ACTIVITY OF BENZIMIDAZOLE DERIVATIVES

https://www.webmedcentral.com/wmcpdf/Article_WMC00656.pdf

Experimental Cancer Treatment: An Emerging Approach

One of the most important goals in medicinal chemistry is the development of new heterocyclic compounds with antitumor activity. Thus, a novel series of Schiff bases 1-11, the derivatives of 2-aryl-1H-benzimidazole has been synthesized and evaluated for their cytotoxic activity against the cells of human cancer cell lines, namely K-562 (myelogenous leukemia) and HL-60 (promyelocytic leukemia). Among the compounds tested against K-562 cell line, compounds 1, 7 and 10 showed potent activity and the compound 5 exhibited better activity against HL-60 cell line.

Mahendra Singh Ranawat

Papers

Synthesis and evaluation of some new benzothiazole derivatives as potential antimicrobial agents.

Original Research Paper SYNTHESIS AND IN VITRO ANTITUMOR ACTIVITY OF BENZIMIDAZOLE DERIVATIVES

Experimental Cancer Treatment: An Emerging Approach

Synthesis and in vitro antitumor activity of benzimidazole derivatives