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Synthesis and in vitro antitumor activity of benzimidazole derivatives
Balram Soni,Mahendra Singh Ranawat,Anil Bhandari,Rambabu Sharma +3 more
- Vol. 2, Iss: 7, pp 6
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TLDR
In this paper, a series of Schiff bases 1-11, the derivatives of 2-aryl-1H-benzimidazole has been synthesized and evaluated for their cytotoxic activity against the cells of human cancer cell lines, namely K-562 (myelogenous leukemia) and HL-60 (promyelocytic leukemia).Abstract:
One of the most important goals in medicinal chemistry is the development of new heterocyclic compounds with antitumor activity. Thus, a novel series of Schiff bases 1-11, the derivatives of 2-aryl-1H-benzimidazole has been synthesized and evaluated for their cytotoxic activity against the cells of human cancer cell lines, namely K-562 (myelogenous leukemia) and HL-60 (promyelocytic leukemia). Among the compounds tested against K-562 cell line, compounds 1, 7 and 10 showed potent activity and the compound 5 exhibited better activity against HL-60 cell line.read more
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Synthesis and Evaluation of Anticancer Benzoxazoles and Benzimidazoles Related to UK-1
TL;DR: Results support a role of Mg(2+) ion binding in the selective cytotoxicity of UK-1 and provide a minimal pharmacophore for the select cytotoxic activity of the natural product.
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Pharmacology and Pharmacotherapeutics
TL;DR: It is concluded that chlorpromazine produces a significant immunological inhibition when administered for 7 days prior to TAB vaccine.
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Synthesis and evaluation of some new benzimidazole derivatives as potential antimicrobial agents
K. F. Ansari,Chhagan Lal +1 more
TL;DR: The efficient synthesis of novel azetidin-2-ones 6 has been established and structures of the synthesized compounds have been elucidated on the basis of their elemental analyses and spectral data.
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Synthesis, antibacterial and antifungal activities of electron-rich olefins derived benzimidazole compounds
TL;DR: Nine of the tested compounds showed an antifungal activity with a range of the MICs between 50 and 400 microg/ml, and none of the compounds exhibit antimicrobial activity against Gram-negative bacteria.
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