M
Mahmoud Benltifa
Researcher at Claude Bernard University Lyon 1
Publications - 8
Citations - 303
Mahmoud Benltifa is an academic researcher from Claude Bernard University Lyon 1. The author has contributed to research in topics: Glycogen phosphorylase & Chemistry. The author has an hindex of 5, co-authored 6 publications receiving 284 citations. Previous affiliations of Mahmoud Benltifa include University of Lyon & Centre national de la recherche scientifique.
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Journal ArticleDOI
1,3-Dipolar cycloaddition reactions on carbohydrate-based templates: synthesis of spiro-isoxazolines and 1,2,4-oxadiazoles as glycogen phosphorylase inhibitors
Mahmoud Benltifa,Sébastien Vidal,David Gueyrard,Peter G. Goekjian,Moncef Msaddek,Jean-Pierre Praly +5 more
TL;DR: In this paper, a 1,3-Dipolar cycloaddition of aryl nitrile oxides to benzyl/acetyl-protected exo -glucals and to a benzoylated glucosyl cyanide led in high yield to spiro-isoxazolines and to 3-aryl-5-glucosyl-1,2,4-oxadiazoles, respectively.
Journal ArticleDOI
Synthesis and structure-activity relationships of C-glycosylated oxadiazoles as inhibitors of glycogen phosphorylase
Marietta Tóth,Sándor Kun,Éva Bokor,Mahmoud Benltifa,Gaylord Tallec,Sébastien Vidal,Tibor Docsa,Pál Gergely,László Somsák,Jean Pierre Praly +9 more
TL;DR: The 5-beta-D-glucopyranosyl-3-(4-methylphenyl- and -2-naphthyl)-1,2,4-oxadiazoles were practically inefficient as inhibitors of rabbit muscle glycogen phosphorylase b while the 2,6-anhydro-aldose benzoylhydrazones displayed inhibitory activities in the micromolar range.
Journal ArticleDOI
Glucose-based spiro-isoxazolines: a new family of potent glycogen phosphorylase inhibitors.
Mahmoud Benltifa,Joseph Hayes,Sébastien Vidal,David Gueyrard,Peter G. Goekjian,Jean-Pierre Praly,Gregory Kizilis,C. Tiraidis,K.-M. Alexacou,Evangelia D. Chrysina,Spyros E. Zographos,Demetres D. Leonidas,Georgios Archontis,Nikos G. Oikonomakos +13 more
TL;DR: Docking calculations with GLIDE in extra-precision (XP) mode yielded excellent agreement with experiment, as judged by comparison of the predicted binding modes of the five ligands with the crystallographic conformations and the good correlation between the docking scores and the experimental free binding energies.
Journal ArticleDOI
In Search of Glycogen Phosphorylase Inhibitors: 5-Substituted 3-C-Glucopyranosyl-1,2,4-oxadiazoles from β-D-Glucopyranosyl Cyanides upon Cyclization of O-Acylamidoxime Intermediates
Mahmoud Benltifa,Sébastien Vidal,Bernard Fenet,Moncef Msaddek,Peter G. Goekjian,Jean Pierre Praly,Attila Brunyanszki,Tibor Docsa,Pál Gergely +8 more
TL;DR: In this paper, a 5-substituted 3-C-β-D-glucopyranosyl-1,2,4-oxadiazole was obtained for the first time.
Journal ArticleDOI
Glucose-based spiro-heterocycles as potent inhibitors of glycogen phosphorylase
Veronika Nagy,Mahmoud Benltifa,Sébastien Vidal,Eszter Berzsényi,Cathie Teilhet,Katalin Czifrák,Gyula Batta,Tibor Docsa,Pál Gergely,László Somsák,Jean-Pierre Praly +10 more
TL;DR: The 2-naphthyl-substituted 1,4,2-oxathiazole displayed the best inhibition against RMGPb (K(i)=160 nM), among glucose-based inhibitors known to date, among glucopyranosylidene-spiro-1,2,4-oxadiazolines.