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Attila Brunyanszki
Researcher at University of Texas Medical Branch
Publications - 26
Citations - 1903
Attila Brunyanszki is an academic researcher from University of Texas Medical Branch. The author has contributed to research in topics: Mitochondrion & Poly ADP ribose polymerase. The author has an hindex of 19, co-authored 25 publications receiving 1612 citations. Previous affiliations of Attila Brunyanszki include Hungarian Academy of Sciences & University of Debrecen.
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Journal ArticleDOI
PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation
Péter Bai,Péter Bai,Carles Cantó,Hugues Oudart,Attila Brunyanszki,Yana Cen,Charles Thomas,Hiroyasu Yamamoto,Aline Huber,Borbála Kiss,Riekelt H. Houtkooper,Kristina Schoonjans,Valérie Schreiber,Anthony A. Sauve,Josiane Ménissier-de Murcia,Johan Auwerx +15 more
TL;DR: The deletion of the poly(ADP-ribose) polymerase-1 (PARP-1) gene, encoding a major NAD(+)-consuming enzyme, increases NAD(+) content and SIRT1 activity in brown adipose tissue and muscle and the pharmacologic inhibition of PARP in vitro and in vivo is shown.
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PARP-2 Regulates SIRT1 Expression and Whole-Body Energy Expenditure
Péter Bai,Péter Bai,Carles Cantó,Attila Brunyanszki,Aline Huber,Magdolna Szántó,Yana Cen,Hiroyasu Yamamoto,Sander M. Houten,Borbála Kiss,Borbála Kiss,Hugues Oudart,Pál Gergely,Josiane Ménissier-de Murcia,Valérie Schreiber,Anthony A. Sauve,Johan Auwerx +16 more
TL;DR: The results indicate that PARP-2 deficiency increases SIRT1 activity in cultured myotubes, however, this increase was not due to changes in NAD(+) levels, but to an increase in SIRT 1 expression, as PARp-2 acts as a direct negative regulator of the SIRT2 promoter.
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Regulation of Vascular Tone, Angiogenesis and Cellular Bioenergetics by the 3-Mercaptopyruvate Sulfurtransferase/H2S Pathway: Functional Impairment by Hyperglycemia and Restoration by dl-α-Lipoic Acid
Ciro Coletta,Katalin Módis,Bartosz Szczesny,Attila Brunyanszki,Gabor Olah,Ester Rios,Kazunori Yanagi,Akbar Ahmad,Andreas Papapetropoulos,Csaba Szabó +9 more
TL;DR: It is concluded that diabetes leads to an impairment of the 3-MST/H2S pathway, and this may contribute to the pathogenesis of hyperglycemia and diabetes-associated vascular complications.
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Mitochondrial DNA damage and subsequent activation of Z-DNA binding protein 1 links oxidative stress to inflammation in epithelial cells
Bartosz Szczesny,Michela Marcatti,Akbar Ahmad,Mauro Montalbano,Attila Brunyanszki,Sofia Iris Bibli,Andreas Papapetropoulos,Andreas Papapetropoulos,Csaba Szabó +8 more
TL;DR: It is proposed that mtDNA-specific damage, and subsequent activation of the ZBP1 pathway, is a mechanism that links prolonged, low-level oxidative stress to autocrine and paracrine inflammation during the early stages of inflammatory lung disease.
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Opposing roles of mitochondrial and nuclear PARP1 in the regulation of mitochondrial and nuclear DNA integrity: implications for the regulation of mitochondrial function
TL;DR: It is concluded that mitochondrial PARP1 exerts a negative effect on several mitochondrial-specific transactions including the repair of the mitochondrial DNA.